Gγ 7 inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of the Gγ 7 protein. Gγ 7, also known as Gamma-7 subunit of G proteins, is a subunit of the heterotrimeric G protein complex. This complex is an integral part of cell signaling pathways and plays a vital role in transducing signals from cell surface receptors to intracellular effectors. G proteins consist of three subunits: α, β, and γ. The Gγ subunit, including Gγ 7, is responsible for anchoring the G protein to the cell membrane and facilitating its interaction with various signaling partners. Inhibitors of Gγ 7 are instrumental in molecular and cellular biology research, allowing scientists to investigate the specific functions and regulatory mechanisms associated with this particular subunit within the broader context of G protein signaling.
The development of Gγ 7 inhibitors typically involves a combination of biochemical, biophysical, and structural techniques aimed at identifying or designing molecules that can bind selectively to Gγ 7 and modulate its activity. By targeting Gγ 7, these inhibitors can disrupt the interactions between G proteins and their downstream signaling partners, thus influencing cellular signaling processes. Researchers use Gγ 7 inhibitors to explore the intricate roles played by G proteins and their subunits, including Gγ 7, in various cellular pathways and physiological responses. Furthermore, these inhibitors serve as valuable tools for dissecting the complex network of cellular processes that rely on G protein-mediated signaling, contributing to our understanding of fundamental cell biology mechanisms and providing insights into avenues for further scientific inquiry.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds to DNA and inhibits RNA synthesis, which could decrease Gγ7 subunit expression by preventing transcription. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Acts as a transcription inhibitor and could reduce Gγ7 expression by blocking the transcription of its gene. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that may cause hypomethylation of the Gγ7 gene, potentially reducing its expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Similar to 5-Azacytidine, it could inhibit DNA methyltransferase, possibly leading to reduced expression of the Gγ7 gene. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Inhibits RNA polymerase II, potentially decreasing the transcription of mRNA for the Gγ7 subunit. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Inhibits protein synthesis and could non-specifically reduce the expression of the Gγ7 subunit. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits eukaryotic protein synthesis and could theoretically lead to a decrease in Gγ7 expression by preventing its translation. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibits RNA polymerase II and could consequently reduce the expression of the Gγ7 subunit. | ||||||
Harringtonin | 26833-85-2 | sc-204771 sc-204771A sc-204771B sc-204771C sc-204771D | 5 mg 10 mg 25 mg 50 mg 100 mg | $250.00 $367.00 $548.00 $730.00 $980.00 | 30 | |
Inhibits protein synthesis by preventing the initial elongation step of translation, which could indirectly reduce Gγ7 subunit levels. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Inhibits peptide bond formation during protein synthesis, possibly leading to a general decrease in protein levels, including Gγ7. | ||||||