Molecular structure of Harringtonin, CAS Number: 26833-85-2
Harringtonin (CAS 26833-85-2)
See product citations (30)
Alternate Names:
Cephalotaxine
Application:
Harringtonin is a natural alkaloid compound with antitumor properties, and an inhibitor of translation.
CAS Number:
26833-85-2
Purity:
≥95%
Molecular Weight:
531.59
Molecular Formula:
C28H37NO9
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Harringtonin is utilized in studies that investigate the process of protein synthesis, particularly to understand the mechanism of ribosomal blocking and the subsequent effects on cellular protein production. It serves as a useful tool in molecular biology for probing the complex initiation steps of mRNA translation, offering insights into the regulation of this fundamental process. Harringtonin is known to interact with a range of molecular targets such as protein kinases, protein phosphatases, and G-protein coupled receptors.
Harringtonin (CAS 26833-85-2) References
- [Effects of harringtonine on peroxidation and dynamic microstructure of membrane lipids of myocardial sarcoplasmic reticulum in rat]. | Zhu, MY., et al. 1997. Zhongguo Yao Li Xue Bao. 18: 90-2. PMID: 10072905
- Cytotoxic anticancer candidates from natural resources. | Kim, J. and Park, EJ. 2002. Curr Med Chem Anticancer Agents. 2: 485-537. PMID: 12678733
- Combinatorial treatment of ovarian cancer cells with harringtonine and cisplatin results in increased cisplatin-DNA adducts. | Yunmbam, MK., et al. 2004. Oncol Rep. 11: 833-8. PMID: 15010881
- Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana. | Tian, Z., et al. 2006. World J Gastroenterol. 12: 874-9. PMID: 16521214
- Altering chemosensitivity by modulating translation elongation. | Robert, F., et al. 2009. PLoS One. 4: e5428. PMID: 19412536
- Inhibition of chikungunya virus replication by harringtonine, a novel antiviral that suppresses viral protein expression. | Kaur, P., et al. 2013. Antimicrob Agents Chemother. 57: 155-67. PMID: 23275491
- PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons. | Biever, A., et al. 2015. J Neurosci. 35: 4113-30. PMID: 25762659
- Assessing the translational landscape of myogenic differentiation by ribosome profiling. | de Klerk, E., et al. 2015. Nucleic Acids Res. 43: 4408-28. PMID: 25873627
- Protein Translation Activity: A New Measure of Host Immune Cell Activation. | Seedhom, MO., et al. 2016. J Immunol. 197: 1498-506. PMID: 27385780
- mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein. | Nofal, M., et al. 2017. Mol Cell. 67: 936-946.e5. PMID: 28918901
- Improved Ribo-seq enables identification of cryptic translation events. | Erhard, F., et al. 2018. Nat Methods. 15: 363-366. PMID: 29529017
- Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors. | Paolini, NA., et al. 2018. PLoS One. 13: e0193790. PMID: 29634759
- Inhibition of translation in eukaryotic systems by harringtonine. | Fresno, M., et al. 1977. Eur J Biochem. 72: 323-30. PMID: 319998
- Harringtonine Ester Derivatives with Enhanced Antiproliferative Activities against HL-60 and HeLa Cells. | Ochi, A., et al. 2022. J Nat Prod. 85: 345-351. PMID: 35148094
- Activity of camptothecin, harringtonin, cantharidin and curcumae in the human tumor stem cell assay. | Jiang, TL., et al. 1983. Eur J Cancer Clin Oncol. 19: 263-70. PMID: 6681771
Inhibitor of:
9930104L06Rik, ABCE1, arfaptin 1, C12orf65_2810006K23Rik, C20orf112, EF-1 ε1, EG628456, EG666806, eRF3b, EVPLL, FXR2, Gγ 7, GEFT, GPI-PLD, H2-Q6, HMX3_Hmx3, hnRNP A0, hnRNP R, IMP-1, JTV1, KIAA0329, KIAA0649, Kua-Uev, LARP4, Lipocalin-3, LOC100040722, LOC642361, LOC645967, LOC646736, Mndal, MOCS1, Nop14, Olfr239, Olr532, Paip2b, PARS2, PRAMEF19, QRSL1, RARS2, RASAL3, RBFA, RBM28, RBMY1D, Ribosomal Protein L35A, Ribosomal Protein L37a, Ribosomal Protein S15, Ribosomal Protein S18, Ribosomal Protein S21, Ribosomal Protein S25, Ribosomal ProteinL18, RPL12, RPL14, RPL15, RPL22L1, RPL24, RPL39, RPL39L, RPLL26L1, Rpp40, SMG5, SMG7, St3Gal-III, TARSL2, TIA1, Tif, Tim14, TINP1, TRAP-α, and UTP14C.Activator of:
CASC3, DENR, EG432502, eRF1, granzyme N, LTV1, MRT4, QM, Rent2, Ribosomal Protein L19, Ribosomal Protein L3, Ribosomal Protein L36a, Ribosomal Protein L4, Ribosomal Protein L7, Ribosomal Protein L9, Ribosomal Protein S10, Ribosomal Protein S15, Ribosomal Protein S17, Ribosomal Protein S29, Ribosomal Protein S7, Ribosomal Protein S8, RPS4Y2, TGIF2LX1, U11/U12 snRNP 20K, UROC1, and UTP14A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Harringtonin, 5 mg | sc-204771 | 5 mg | $250.00 | |||
| US: (Out of Stock: Availability February 18, 2026) | ||||||
Harringtonin, 10 mg | sc-204771A | 10 mg | $367.00 | |||
Harringtonin, 25 mg | sc-204771B | 25 mg | $548.00 | |||
Harringtonin, 50 mg | sc-204771C | 50 mg | $730.00 | |||
Harringtonin, 100 mg | sc-204771D | 100 mg | $980.00 | |||