Gα i-3 Inhibitors
Common Gα i-3 Inhibitors include, but are not limited to Pertussis Toxin (islet-activating protein) CAS 70323-44-3, NF 023 CAS 104869-31-0, NF449 CAS 627034-85-9, Methyl-β-cyclodextrin CAS 128446-36-6 and WZ811 CAS 55778-02-4.
Gαi-3 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of the G protein subunit alpha i-3 (Gαi-3). Gαi-3 is a member of the G protein family, which plays a crucial role in transducing signals from cell surface receptors to intracellular signaling pathways. It is one of the several isoforms of the Gαi family and is involved in mediating the inhibition of adenylate cyclase, thereby downregulating cyclic adenosine monophosphate (cAMP) production. This, in turn, leads to the modulation of various cellular processes, including cell proliferation, neurotransmitter release, and hormonal signaling.
Gαi-3 inhibitors work by specifically targeting the Gαi-3 protein, interfering with its ability to interact with cell surface receptors and activate downstream signaling pathways. By doing so, these inhibitors may modulate the cellular response to extracellular stimuli and affect various physiological processes regulated by Gαi-3-mediated signaling. Research into Gαi-3 and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in cellular signaling. The study of Gαi-3 inhibitors represents an intriguing area of research, contributing to a deeper understanding of the intricacies of G protein signaling and its impact on cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
YM 254890 | 568580-02-9 | sc-507356 | 1 mg | $510.00 | ||
Inhibits Gαi signaling by preventing the dissociation of Gαi subunit from Gβγ complex, leading to the inhibition of downstream signaling pathways. Used in research to study Gαi-mediated cellular responses. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Bacterial toxin that ADP-ribosylates Gαi-3, inhibiting its interaction with G-protein coupled receptors (GPCRs), thereby disrupting Gαi-mediated signaling pathways and perturbing cellular responses. | ||||||
FR 900359 | 107530-18-7 | sc-507357 | 500 µg | $226.00 | ||
Irreversibly inhibits Gαi signaling by directly binding and blocking Gαi from interacting with its effector enzymes, leading to the inhibition of downstream signaling pathways. Used in research to study Gαi-3-mediated cellular responses. | ||||||
NF 023 | 104869-31-0 | sc-204124 sc-204124A | 10 mg 50 mg | $161.00 $629.00 | 1 | |
Potent inhibitor of Gαi signaling by blocking Gαi-coupled P2Y receptors, leading to the inhibition of downstream signaling cascades. Used in research for studying Gαi-3-mediated responses to nucleotides. | ||||||
VX-11e | 896720-20-0 | sc-507301 | 10 mg | $180.00 | ||
Selectively inhibits Gαi/o proteins, including Gαi-3, interfering with GPCR-mediated Gαi signaling and downstream cellular responses. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $203.00 $469.00 $1509.00 | 1 | |
Potent inhibitor of Gαi signaling by blocking Gαi-coupled P2X1 receptors, leading to the inhibition of downstream signaling cascades. Used in research for studying Gαi-3-mediated responses to purinergic ligands. | ||||||
CCG 203971 | 1443437-74-8 | sc-507360 | 10 mg | $89.00 | ||
Selectively inhibits Gαi/o proteins, including Gαi-3, interfering with GPCR-mediated Gαi signaling and downstream cellular responses. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
Indirectly inhibits Gαi-3 signaling by depleting cellular cholesterol, leading to the disruption of lipid rafts and GPCR localization, affecting Gαi-mediated signaling pathways. | ||||||
YODA 1 | 448947-81-7 | sc-507361 | 10 mg | $215.00 | ||
Activates Gαi/o proteins, including Gαi-3, leading to the modulation of cellular responses mediated by Gαi signaling pathways. Its use as an inhibitor is context-dependent. | ||||||
WZ811 | 55778-02-4 | sc-296701 sc-296701A | 1 mg 5 mg | $29.00 $66.00 | ||
Inhibits Gαi3 signaling by blocking the interaction between Gαi3 and regulator of G-protein signaling (RGS) proteins, leading to the inhibition of downstream signaling pathways. Used in research to study Gαi-3-mediated cellular responses. | ||||||