FXR Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GW 4064 | 278779-30-9 | sc-218577 | 5 mg | $93.00 | 13 | |
GW 4064 (CAS 278779-30-9) is a chemical compound that activates FXR, a nuclear receptor involved in regulating various physiological processes. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $230.00 | ||
Thrombin can indirectly activate FX through feedback activation of FVII. Thrombin also activates other clotting factors, amplifying the coagulation cascade. | ||||||
SR 12813 | 126411-39-0 | sc-204296 sc-204296A | 10 mg 50 mg | $89.00 $338.00 | ||
SR 12813 (CAS 126411-39-0) is a compound that activates FXR, a nuclear receptor associated with the regulation of various physiological processes. | ||||||
Fexaramine | 574013-66-4 | sc-203580 sc-203580A | 10 mg 50 mg | $398.00 $1380.00 | 1 | |
Fexaramine (CAS 574013-66-4) is a chemical compound that activates FXR, a nuclear receptor involved in the modulation of diverse physiological processes. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $68.00 | 30 | |
GW4064 is a synthetic FXR agonist that was developed as a research tool to study FXR activation. It activates FXR in a manner similar to natural bile acids by binding to the receptor and promoting the transcription of target genes. GW4064 has been used in various experimental settings to explore FXR-mediated effects on metabolism and other physiological processes. | ||||||
Chenodeoxycholic acid, free acid | 474-25-9 | sc-278835 sc-278835A | 1 g 5 g | $27.00 $115.00 | ||
CDCA is a primary bile acid that activates the farnesoid X receptor (FXR). When CDCA binds to FXR, it triggers the formation of FXR-RXR heterodimers, which then bind to specific DNA sequences in target gene promoters. This binding leads to the transcription of genes responsible for regulating bile acid synthesis, transport, and metabolism. This mechanism helps maintain the balance of bile acids in the body and supports the feedback regulation of bile acid levels. | ||||||
Ursodeoxycholic acid | 128-13-2 | sc-204935 sc-204935A | 1 g 5 g | $51.00 $128.00 | 4 | |
UDCA is a primary bile acid that has been shown to activate FXR. Similar to CDCA, UDCA binds to FXR and induces the formation of FXR-RXR heterodimers. This leads to the activation of genes involved in bile acid transport and detoxification. UDCA is often used therapeutically to treat certain liver disorders, and its FXR-mediated effects contribute to its beneficial effects on bile acid metabolism. | ||||||