SR 12813 CAS: 126411-39-0
MF: C24H42O7P2
MW: 504.53
A PXR agonist that activates the farnesoid X receptor (FXR) at μM concentrations.

SR 12813 (CAS 126411-39-0)

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Synonym: 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol
Application: A PXR agonist that activates the farnesoid X receptor (FXR) at μM concentrations
CAS Number: 126411-39-0
Purity: 98%
Molecular Weight: 504.53
Molecular Formula: C24H42O7P2
* Refer to Certificate of Analysis for lot specific data (including water content).
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SR 12813 is a PXR (pregnane X receptor) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). SR 12813 activates the FXR (farnesoid X receptor) at μM concentrations. SR 12813 is an inhibitor of HMGCR.


References

Berkhout et al (1996) The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J.Biol.Chem. 271 14376. Jones et al (2000) The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol.Pharmacol. 14 27. Lemaire et al (2007) Discovery of a highly active ligand of human pregnane X receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity. Mol.Pharmacol. 72 572.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM). Insoluble in water.
Storage :
Store at 4° C
Boiling Point :
552.64° C at 760 mmHg (Predicted)
Density :
1.12 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
PXR: EC5050 = 200 nM (human); PXR: EC5050 = 700 nM (rabbit)
pK Values :
pKa: 9.95 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
446313
MDL Number :
MFCD00888473
SMILES :
CCOP(=O)(C(=CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C)P(=O)(OCC)OCC)OCC

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Certificate of Analysis

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