Fexaramine CAS: 574013-66-4
MF: C32H36N2O3
MW: 496.64
A potent, selective FXR activator.

Fexaramine (CAS 574013-66-4)

Fexaramine | CAS 574013-66-4 is rated 5.0 out of 5 by 1.
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Synonym: 3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid, methyl ester
Application: A potent, selective FXR activator
CAS Number: 574013-66-4
Purity: ≥97%
Molecular Weight: 496.64
Molecular Formula: C32H36N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Fexaramine is a potent, selective FXR (farnesoid X receptor) agonist (EC50 = 25 nM). Fexaramine displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.


References

1. Nicolaou, K.C., et al. 2003. Org. Biomol. Chem. 1: 908-920.
2. Downes, M., et al,. 2003. Mol. Cell 11: 1079-1092.
3. Pellicciari, R., et al. 2006. J. Med. Chem. 49: 4208-4215.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Desiccate at 4° C
Melting Point :
274.84° C (Predicted)
Boiling Point :
~677.7° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
farnesoid X receptor agonist: EC5050 = 25 nM
pK Values :
pKb: 4.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5326713
MDL Number :
MFCD09971007
SMILES :
CN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CN(C3=CC=CC(=C3)/C=C/C(=O)OC)C(=O)C4CCCCC4

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Certificate of Analysis

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How stable is fexaramine at room temperature? We plan to use this in a chow diet in mice.

Asked by: marcelsorribas
Thank you for your question. The ideal storage conditions for fexaramine are desiccated at 4° C. We do not recommend storing the compound in an aquaeous solution for more than a day.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06

What is the solubility in DMSO?

Asked by: chemsd02
Thank you for your question. sc-203580 (Fexaramine, CAS 574013-66-4) is soluble in DMSO up to 10 mg/mL.
Answered by: Chemical Support 10
Date published: 2017-03-09
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Rated 5 out of 5 by from Fang et al Fang et al. (PubMed ID 25559344) found that fexaramine induced enteric fibroblast growth factor 15 (FGF15), leading to alterations in BA composition and reduction of diet-induced weight gain. -SCBT Publication Review
Date published: 2015-02-13
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