MF: C32H36N2O3 MW: 496.64 A potent, selective FXR activator.
Protein-Interacting Inhibitors, Activators & Substrates
Fexaramine (CAS 574013-66-4)
3-[3-[(cyclohexylcarbonyl)[[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid, methyl ester
Fexaramine is a potent, selective FXR activator
C 32H 36N 2O 3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. *
Certificate of Analysis for lot specific data (including water content).
Click on image or enlarge button to enlarge
Fexaramine is a potent, selective FXR (farnesoid X receptor) agonist (EC
50 = 25 nM). Fexaramine displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors. References
1. Nicolaou, K.C., et al. 2003. Org. Biomol. Chem. 1: 908-920.
2. Downes, M., et al,. 2003. Mol. Cell 11: 1079-1092. 3. Pellicciari, R., et al. 2006. J. Med. Chem. 49: 4208-4215.
Soluble in DMSO (100 mM).
Desiccate at 4° C
274.84° C (Predicted)
~677.7° C at 760 mmHg (Predicted)
20 D 1.63 (Predicted)
farnesoid X receptor agonist: EC
5050 = 25 nM
b: 4.96 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents
How stable is fexaramine at room temperature? We plan to use this in a chow diet in mice.
Thank you for your question. The ideal storage conditions for fexaramine are desiccated at 4° C. We do not recommend storing the compound in an aquaeous solution for more than a day.
Date published: 2019-01-06
What is the solubility in DMSO?
Thank you for your question. sc-203580 (Fexaramine, CAS 574013-66-4) is soluble in DMSO up to 10 mg/mL.
Date published: 2017-03-09
Rated 5 out of
Fang et al
Fang et al. (PubMed ID 25559344) found that fexaramine induced enteric fibroblast growth factor 15 (FGF15), leading to alterations in BA composition and reduction of diet-induced weight gain. -SCBT Publication Review
Date published: 2015-02-13
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.