FRP1 Inhibitors
FRP1 inhibitors are a class of chemical compounds that target the Frizzled-Related Protein 1 (FRP1), a member of the cysteine-rich family of proteins involved in cellular signaling. These inhibitors primarily work by modulating the activity of FRP1, a protein that interacts with the Wnt signaling pathway, which is crucial for various cellular processes, including differentiation, migration, and proliferation. The Wnt pathway functions through a network of proteins that includes Frizzled receptors, and FRP1 acts as a regulatory element within this system. By inhibiting FRP1, these compounds can alter the downstream signaling events, impacting gene expression, protein interactions, and cellular behavior. Structurally, FRP1 inhibitors are often small molecules designed to interfere with the binding of FRP1 to its natural ligands or other associated proteins, thus disrupting its normal function.
The chemical structure of FRP1 inhibitors can vary widely, but they typically include functional groups that allow for high specificity in binding to the FRP1 protein, often through hydrophobic interactions, hydrogen bonding, or van der Waals forces. These inhibitors are usually characterized by their ability to effectively block the interaction between FRP1 and its targets without affecting other components of the Wnt pathway, thereby offering a precise method of modulation. In many cases, these inhibitors are developed using rational design approaches, where the structure of FRP1 is analyzed in detail to identify binding pockets or domains that can be targeted. These molecules are then optimized for potency and selectivity through iterative chemical modifications, allowing for fine-tuning of their activity at a molecular level. The specificity of FRP1 inhibitors is critical to their ability to precisely regulate cellular pathways where FRP1 plays a role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is known to inhibit protein kinase C, which could lead to the downregulation of FRP1 expression by altering transcription factor activity specifically associated with the FRP1 gene promoter. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine may cause hypomethylation of the FRP1 gene promoter, resulting in the decreased transcriptional activity of the FRP1 gene and subsequent reduced expression of the protein. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to specific DNA sequences and could selectively inhibit the transcription of the FRP1 gene by preventing transcription factor binding, leading to a decrease in FRP1 protein synthesis. | ||||||
Triapine | 200933-27-3 | sc-475303 | 10 mg | $300.00 | ||
Triapine can chelate intracellular iron, lowering the availability of the iron required for FRP1 function. This could trigger cellular mechanisms that sense iron levels and subsequently downregulate FRP1 expression to conserve resources. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate inhibits histone deacetylase, which can lead to the unwinding of chromatin structure around the FRP1 gene. This change can suppress the initiation of transcription, leading to reduced expression of FRP1. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 specifically inhibits MEK, which in turn can inhibit ERK phosphorylation. Since ERK is often involved in signaling pathways that control gene expression, inhibition by PD98059 could decrease FRP1 gene expression through these pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a peptide aldehyde that inhibits the ubiquitin-proteasome pathway. This inhibition could lead to the accumulation of certain transcription factors in their inactive form, which in turn could prevent the activation of the FRP1 gene expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D intercalates into DNA and inhibits RNA polymerase movement, which could specifically inhibit the transcriptional elongation of the FRP1 gene, leading to a dramatic decrease in FRP1 mRNA and protein levels. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid with antioxidant properties, can inhibit the phosphorylation of specific transcription factors, which might be necessary for the transcription of the FRP1 gene. This could result in a decreased expression of FRP1. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram covalently modifies and inactivates the copper chaperone protein Atox1, potentially leading to a decrease in copper availability within the cell. The cell may respond by downregulating copper-dependent proteins such as FRP1 to conserve copper. | ||||||