frizzled-4 Inhibitors

LGK-974 is a porcupine inhibitor that indirectly influences frizzled-4 by targeting the Wnt signaling pathway. It inhibits porcupine, an acyltransferase involved in Wnt secretion, thereby preventing the palmitoylation of Wnt ligands. This disruption leads to the inhibition of the Wnt pathway, impacting frizzled-4 activation and downstream signaling.

IWP-2 is a Wnt production inhibitor that indirectly modulates frizzled-4. It inhibits the secretion of Wnt ligands by targeting the enzyme porcupine. By blocking Wnt production, IWP-2 disrupts the Wnt signaling pathway, affecting the activation of frizzled-4 and downstream signaling cascades.

KY02111 is a Wnt/β-catenin signaling inhibitor that indirectly impacts frizzled-4. It interferes with the interaction between β-catenin and TCF/LEF transcription factors, suppressing Wnt-dependent gene transcription. This inhibition of Wnt/β-catenin signaling can downregulate frizzled-4 activation and modulate its cellular effects.

NSC 668036 is a tankyrase inhibitor that indirectly influences frizzled-4 by modulating the canonical Wnt pathway. It stabilizes Axin, a component of the β-catenin destruction complex, preventing β-catenin from translocating to the nucleus. This disruption of Wnt signaling can impact frizzled-4 activity and downstream signaling events.

XAV939 is a tankyrase inhibitor that indirectly inhibits frizzled-4 by targeting the Wnt/β-catenin pathway. It promotes the stabilization of Axin, leading to increased degradation of β-catenin. The inhibition of Wnt signaling through XAV939 can modulate frizzled-4 activation and downstream cellular responses.

PRI-724 is a CBP/β-catenin inhibitor that indirectly influences frizzled-4 by targeting the Wnt/β-catenin pathway. It disrupts the interaction between β-catenin and CBP, inhibiting the transcriptional activity of β-catenin. This interference with Wnt signaling can impact frizzled-4 activation and downstream cellular processes.

Calphostin C is a tankyrase inhibitor that indirectly modulates frizzled-4 through the regulation of the Wnt/β-catenin pathway. By stabilizing Axin and promoting the degradation of β-catenin, Calphostin C disrupts Wnt signaling, influencing frizzled-4 activation and downstream signaling cascades.

C59 is a porcupine inhibitor that indirectly impacts frizzled-4 by targeting Wnt ligand secretion. It inhibits porcupine, preventing the acylation of Wnt ligands and their secretion. This disruption of Wnt signaling influences frizzled-4 activation, modulating downstream cellular responses through the canonical Wnt pathway.

IWR-1-endo is a tankyrase inhibitor that indirectly modulates frizzled-4 by affecting the Wnt/β-catenin pathway. It stabilizes Axin, leading to increased degradation of β-catenin and inhibition of Wnt signaling. This interference with the Wnt pathway influences frizzled-4 activation and downstream cellular responses.

G007-LK is a tankyrase inhibitor that indirectly influences frizzled-4 through the regulation of Wnt/β-catenin signaling. By stabilizing Axin and promoting the degradation of β-catenin, G007-LK disrupts the Wnt pathway, impacting frizzled-4 activation and downstream cellular processes.