Fragilis Activators
Fragilis, a member of the interferon-inducible transmembrane (IFITM) protein family, plays a crucial role in a myriad of biological processes, including the regulation of cellular immunity. It is known that the expression of Fragilis can be influenced by a diverse array of compounds, which can lead to a heightened state of immune readiness within cells. The mechanisms through which these compounds enhance Fragilis expression are varied and complex, involving intricate signaling pathways that converge on the genetic control elements responsible for the transcription of the Fragilis gene. Such compounds, which are not limited to but include certain small molecules, vitamins, and other non-protein chemical agents, could potentially serve as activators of Fragilis expression.
One compelling example of an activator is retinoic acid, a derivative of vitamin A, which is implicated in the regulation of genes associated with immune response and cell differentiation. Through its action on specific nuclear receptors, retinoic acid can upregulate the expression of Fragilis, highlighting the role of dietary compounds in the modulation of immune-related genes. Similarly, lipopolysaccharides (LPS), molecules found on the outer membrane of Gram-negative bacteria, can also enhance Fragilis expression by engaging toll-like receptor 4 (TLR4). This receptor-mediated pathway exemplifies how the immune system utilizes components of pathogens to bolster its defensive lines. Other activators, such as sodium butyrate and 5-Azacytidine, affect the chromatin state and DNA methylation patterns, respectively, and these epigenetic modifications can lead to increased transcription of Fragilis. The interplay between these activators and the cellular machinery that governs gene expression is a testament to the complexity of the regulatory networks that define the cellular response to environmental cues. Understanding how Fragilis expression is controlled by various bioactive compounds is a subject of intense research, shedding light on the sophisticated nature of gene regulation within the context of immune function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid engages with retinoic acid receptors to initiate transcriptional events, which can lead to the upregulation of Fragilis as part of the cell's differentiation processes in the immune system. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS activates TLR4, initiating a signaling cascade that can stimulate a broad immune response, including the upregulation of Fragilis, enhancing cellular defenses against pathogens. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can cause an increase in histone acetylation, relaxing chromatin and potentially leading to an increase in Fragilis expression through enhanced gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methylation, 5-Azacytidine can lead to the reactivation of epigenetically silenced genes, which may include the gene encoding Fragilis, resulting in its increased expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA can activate protein kinase C (PKC), which may trigger a series of intracellular events culminating in the increased transcription of Fragilis, particularly in immune cells. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol, through its hormonal action, can influence the expression of genes involved in the immune response, which may include stimulating the production of Fragilis to aid in cellular defense mechanisms. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod activates immune cells via toll-like receptor 7 and may lead to the induction of Fragilis expression as part of the innate immune response to viral infections. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide has been shown to influence immune function and may stimulate the expression of Fragilis through its effects on cytokine production and immune cell modulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been reported to stimulate the expression of genes linked to longevity and stress resistance, which may include Fragilis, through pathways such as SIRT1 activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, leading to the activation of PKA and potentially other signaling molecules that could stimulate the transcription and expression of Fragilis. | ||||||