FOXO4 Inhibitors
FOXO4 inhibitors are a class of chemical compounds designed to selectively interfere with the activity of the FOXO4 (Forkhead Box O4) transcription factor. FOXO4 is a member of the Forkhead box O (FOXO) family of proteins, which are known to play a significant role in regulating the expression of genes involved in various cellular processes such as apoptosis, autophagy, and cell cycle control. FOXO proteins, including FOXO4, act as transcriptional regulators that can bind to specific DNA sequences, modulating the expression of target genes in response to various environmental and intracellular signals. FOXO4 activity is tightly controlled by post-translational modifications, such as phosphorylation, acetylation, and ubiquitination, which can either activate or inhibit its function.
FOXO4 inhibitors work by disrupting the interactions between FOXO4 and its binding partners or by modifying its localization and stability within the cell. Some inhibitors are designed to prevent FOXO4 from translocating to the nucleus, where it would otherwise bind to DNA and activate transcription of its target genes. Others may block the dimerization or interaction of FOXO4 with other co-regulators, thereby reducing its transcriptional activity. These inhibitors are often characterized by their ability to modulate the oxidative stress response and cellular senescence, processes in which FOXO4 plays a crucial role. Structurally, these compounds can vary, ranging from small molecules to peptides, and are often optimized for their ability to selectively target FOXO4 without affecting other FOXO family members, ensuring greater specificity in their action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 may downregulate FOXO4 expression by inhibiting PI3K, leading to reduced AKT-mediated phosphorylation and nuclear export of FOXO4, which could stabilize its transcriptional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin could decrease FOXO4 expression through PI3K inhibition, subsequently diminishing AKT activity and potentially enhancing FOXO4's presence in the nucleus, thereby influencing its expression. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine may suppress AKT activation, which in turn might prevent FOXO4 nuclear export and degradation, potentially resulting in an elevation of FOXO4's transcriptional activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol may induce cellular stress that can lead to the activation of FOXO4-dependent apoptotic pathways, potentially increasing FOXO4 expression as a pro-apoptotic response. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate, as an antioxidant, may prompt an oxidative stress response that could lead to the upregulation of FOXO4 expression, positioning FOXO4 as a mediator of cell survival and apoptosis. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Sodium salicylate could reduce the inhibitory action of NF-kB on FOXO4, potentially resulting in an upswing in FOXO4 expression due to diminished NF-kB-mediated suppression. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib may downregulate receptor tyrosine kinases which could result in reduced signaling through pathways that normally lead to FOXO4 inhibition, thereby potentially increasing FOXO4 expression. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane may stimulate the Nrf2 pathway and thereby could upregulate FOXO4 expression as part of the cellular defense mechanism against oxidative stress. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
By inhibiting HSP90, 17-AAG could destabilize proteins that promote FOXO4 degradation, potentially leading to increased FOXO4 stability and expression. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin's activation of AMPK could lead to a decrease in mTOR signaling, which may remove inhibitory signals on FOXO4, potentially resulting in elevated FOXO4 expression. | ||||||