FOXD4L5 Inhibitors
FOXD4L5 inhibitors represent a chemical class that targets the transcription factor FOXD4-like 5, a member of the forkhead box (FOX) family of proteins. These proteins are characterized by a conserved DNA-binding domain known as the "forkhead" or "winged-helix" domain, which interacts with specific DNA sequences to regulate the expression of genes involved in various biological processes. Inhibitors of FOXD4L5 function by interfering with the transcriptional activity of this particular protein, thereby modulating the expression of downstream target genes. The mechanism of inhibition typically involves either direct binding to the protein's DNA-binding domain or disruption of the protein's interactions with co-factors necessary for its regulatory functions.
Inhibitors of FOXD4L5 are of particular interest due to the role of the FOXD4-like proteins in developmental pathways, cell differentiation, and cellular homeostasis. By modulating the activity of FOXD4L5, these inhibitors can alter key transcriptional networks that govern processes such as cell cycle regulation, apoptosis, and metabolic control. The specificity and potency of FOXD4L5 inhibitors can vary based on their chemical structure, which may include small molecules or peptides designed to interact with precise regions of the protein. These inhibitors are often investigated for their ability to elucidate the complex signaling pathways regulated by FOX proteins and to explore the broader roles of transcription factors in cellular function and regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 inhibits PI3K, which is crucial for the activation of AKT signaling; with AKT inhibited, downstream targets including the Forkhead box protein D4-like 5, which relies on AKT for full activation, will also be inhibited. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 inhibits MEK, which is upstream of ERK in the MAPK/ERK pathway; Forkhead box protein D4-like 5 is regulated by this pathway, and inhibition of MEK leads to reduced ERK activity and therefore inhibition of Forkhead box protein D4-like 5. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAP kinase pathway which can regulate Forkhead box protein D4-like 5 activity; by inhibiting JNK, the phosphorylation and activation of Forkhead box protein D4-like 5 are reduced. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 specifically inhibits p38 MAP kinase, which can control the activity of Forkhead box protein D4-like 5; inhibition of p38 MAP kinase leads to decreased activation of Forkhead box protein D4-like 5. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, preventing the activation of the ERK pathway, which is involved in the regulation of Forkhead box protein D4-like 5 activity; inhibition of this pathway leads to the reduction of Forkhead box protein D4-like 5 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor; by inhibiting PI3K, it prevents the activation of downstream targets including AKT, which in turn would inhibit the activity of Forkhead box protein D4-like 5 through lack of activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a downstream component of the PI3K/AKT pathway, which is known to regulate Forkhead box protein D4-like 5; by inhibiting mTOR, the activity of Forkhead box protein D4-like 5 is reduced. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF 109203X is a PKC inhibitor; since PKC can phosphorylate and activate several proteins including Forkhead box protein D4-like 5, its inhibition leads to decreased Forkhead box protein D4-like 5 activity. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a broad-spectrum PKC inhibitor, which would decrease the activity of PKC-dependent pathways, reducing the phosphorylation and hence activity of Forkhead box protein D4-like 5. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP 2 is an Src family kinase inhibitor; Src kinases can phosphorylate and influence the activity of several proteins, including Forkhead box protein D4-like 5, and inhibition by PP 2 would result in decreased activity of Forkhead box protein D4-like 5. | ||||||