FNDC8 Activators
FNDC8 Activators are chemicals that function through a range of biochemical mechanisms to induce the activation of FNDC8. One major category consists of chemicals like Resveratrol and Metformin that act via specific cellular kinases and transcription factors. For instance, Resveratrol activates SIRT1, which indirectly upregulates FNDC8 expression by deacetylating key transcription factors. Metformin activates AMPK, leading to changes in gene expression that include increased FNDC8 levels.
Another category includes chemicals that work through modifying the cellular environment, such as Trolox, which enhances cellular antioxidants, thus creating a milieu that is conducive for FNDC8 activation. Chemicals like Quercetin and Curcumin act through the Nrf2 pathway to affect FNDC8 activation. These chemicals essentially modify either the activity of specific molecules involved in FNDC8 regulation or alter the cellular environment in a manner conducive to FNDC8 activation. Both categories offer specific yet interconnected routes to facilitate the activation of FNDC8 without inhibitory effects.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates SIRT1 which upregulates FNDC8 expression indirectly through deacetylation of transcription factors. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Activates AMPK, which can lead to FNDC8 activation by promoting transcription factors that regulate FNDC8 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase leading to increased cAMP levels, enhancing PKA activity which may target FNDC8 for activation. | ||||||
Trolox | 53188-07-1 | sc-200810 sc-200810A sc-200810B sc-200810C sc-200810D | 500 mg 1 g 5 g 25 g 100 g | $38.00 $67.00 $235.00 $678.00 $1712.00 | 39 | |
A vitamin E analog that enhances cellular antioxidants, possibly creating an environment conducive for FNDC8 activation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
Activates AMPK, influencing pathways that indirectly lead to FNDC8 activation by altering gene expression. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Inhibits glycolysis and activates stress response pathways that might indirectly activate FNDC8 through kinases or transcription factors. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Activates Nrf2, leading to transcriptional activation of FNDC8 through antioxidant response elements. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Activates Nrf2 and related pathways, leading to conditions that promote FNDC8 activation. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Inhibits phosphodiesterases leading to increased cAMP, which may indirectly activate FNDC8 through PKA. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Activates PKC, which may indirectly activate FNDC8 by altering its phosphorylation state. | ||||||