FN3KRP Inhibitors
FN3KRP contain inhibitor compounds such as Alloxan and Streptozotocin can alter the cellular redox environment and DNA integrity, respectively, which can indirectly influence the function of FN3KRP, possibly by affecting the enzyme's expression or stability. Aminoguanidine and Pyridoxamine act by interfering with the formation of AGEs, thus potentially reducing the accumulation of substrates that FN3KRP might act upon. This reduction in substrate availability can translate to decreased FN3KRP activity.
On a broader scale, agents like Rosiglitazone and Metformin that modify glucose metabolism and energy regulation pathways can lead to changes in intracellular glycation levels. These changes, in turn, can have downstream effects on FN3KRP's role in repairing glycated proteins. Other molecules, including anti-inflammatory and antioxidant compounds such as Acetylsalicylic acid, Rutin, Quercetin, Ascorbic acid, Taurine, and EGCG, can influence systemic levels of glycation and oxidative stress. By modulating these states, they can alter the extent of protein glycation and thereby potentially affect the functional demand on FN3KRP.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alloxan monohydrate | 2244-11-3 | sc-254940 | 10 g | $54.00 | ||
Generates reactive oxygen species upon glucose metabolism, can disrupt cellular redox states, possibly affecting FN3KRP function.c | ||||||
Streptozotocin (U-9889) | 18883-66-4 | sc-200719 sc-200719A | 1 g 5 g | $116.00 $530.00 | 152 | |
Alkylating agent that targets pancreatic beta cells and can induce DNA damage, potentially perturbing FN3KRP activity. | ||||||
Aminoguanidine hydrochloride | 1937-19-5 | sc-202931 sc-202931A sc-202931B | 10 g 25 g 50 g | $32.00 $43.00 $94.00 | 2 | |
Inhibits the formation of advanced glycation end-products (AGEs), which may reduce substrate availability for FN3KRP. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
PPAR-gamma agonist, may affect glucose metabolism and indirectly influence FN3KRP activity by altering glycation levels. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Activates AMPK, leading to altered glucose metabolism, which may reduce the glycation that FN3KRP usually repairs. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Can modulate glycation processes, potentially altering the substrate landscape for FN3KRP. | ||||||
Rutin trihydrate | 250249-75-3 | sc-204897 sc-204897A sc-204897B | 5 g 50 g 100 g | $57.00 $72.00 $126.00 | 7 | |
Flavonoid with antioxidant properties, can modulate glycation and inflammation, indirectly affecting FN3KRP's role. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Another flavonoid that can modulate glycation and oxidative stress, possibly influencing FN3KRP activity. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Antioxidant that may impact glycation levels and therefore FN3KRP's function in repairing glycated proteins. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
May reduce glycation and oxidative stress, possibly impacting FN3KRP activity. | ||||||