FN3KRP Antibody (G-1): sc-376717
- FN3KRP Antibody (G-1) is a mouse monoclonal IgG1 κ FN3KRP antibody provided at 200 µg/ml
- raised against amino acids 143-202 mapping within an internal region of FN3KRP of human origin
- FN3KRP Antibody (G-1) is recommended for detection of FN3KRP of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FN3KRP Antibody (G-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FN3KRP Antibody (G-1) for WB applications. These reagents are now offered in bundles with FN3KRP Antibody (G-1) (see ordering information below).
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FN3KRP Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects FN3KRP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FN3KRP (G-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FN3KRP protein, a member of the fructosamine kinase family, plays a crucial role in phosphorylating psicoamines and ribulosamines, specifically targeting the third carbon of their sugar moiety. This post-translational modification leads to deglycation of target amines, protecting proteins from nonenzymatic glycation′s detrimental effects, which can cause cellular dysfunction and contribute to various diseases, including diabetes and aging-related disorders. FN3KRP is predominantly expressed in erythrocytes, bone marrow, spleen, brain, and kidney, highlighting FN3KRP′s importance in maintaining cellular health and metabolic processes across different tissues. Using anti-FN3KRP antibody (G-1) in research can provide valuable insights into glycation mechanisms and fructosamine kinases′ protective roles in cellular metabolism.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FN3KRP Antibody (G-1) References:
- A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines. | Collard, F., et al. 2003. Diabetes. 52: 2888-95. PMID: 14633848
- Fructosamine 3-kinase-related protein and deglycation in human erythrocytes. | Collard, F., et al. 2004. Biochem J. 382: 137-43. PMID: 15137908
- The expression of the genes for fructosamine-3-kinase and fructosamine-3-kinase-related protein appears to be constitutive and unaffected by environmental signals. | Conner, JR., et al. 2004. Biochem Biophys Res Commun. 323: 932-6. PMID: 15381090
- Some clues as to the regulation, expression, function, and distribution of fructosamine-3-kinase and fructosamine-3-kinase-related protein. | Conner, JR., et al. 2005. Ann N Y Acad Sci. 1043: 824-36. PMID: 16037310
- Fructosamine-6-phosphates are deglycated by phosphorylation to fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP). | Szwergold, BS. 2007. Med Hypotheses. 68: 37-45. PMID: 16920277
- Fructosamine-3-kinase-related-protein phosphorylates glucitolamines on the C-4 hydroxyl: novel substrate specificity of an enigmatic enzyme. | Szwergold, B., et al. 2007. Biochem Biophys Res Commun. 361: 870-5. PMID: 17686456
- Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5'-[p-(fluorosulfonyl)benzoyl]adenosine. | Payne, LS., et al. 2008. Biochem J. 416: 281-8. PMID: 18637789
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FN3KRP Antibody (G-1) | sc-376717 | 200 µg/ml | $322.00 | |||
FN3KRP Antibody (G-1): m-IgGκ BP-HRP Bundle | sc-523060 | 200 µg Ab, 40 µg BP | $361.00 | |||
FN3KRP Antibody (G-1): m-IgG1 BP-HRP Bundle | sc-533549 | 200 µg Ab; 20 µg BP | $361.00 | |||
FN3KRP Antibody (G-1) AC | sc-376717 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FN3KRP Antibody (G-1) HRP | sc-376717 HRP | 200 µg/ml | $322.00 | |||
FN3KRP Antibody (G-1) FITC | sc-376717 FITC | 200 µg/ml | $336.00 | |||
FN3KRP Antibody (G-1) PE | sc-376717 PE | 200 µg/ml | $349.00 | |||
FN3KRP Antibody (G-1) Alexa Fluor® 488 | sc-376717 AF488 | 200 µg/ml | $364.00 | |||
FN3KRP Antibody (G-1) Alexa Fluor® 546 | sc-376717 AF546 | 200 µg/ml | $364.00 | |||
FN3KRP Antibody (G-1) Alexa Fluor® 594 | sc-376717 AF594 | 200 µg/ml | $364.00 | |||
FN3KRP Antibody (G-1) Alexa Fluor® 647 | sc-376717 AF647 | 200 µg/ml | $364.00 | |||
FN3KRP Antibody (G-1) Alexa Fluor® 680 | sc-376717 AF680 | 200 µg/ml | $364.00 | |||
FN3KRP Antibody (G-1) Alexa Fluor® 790 | sc-376717 AF790 | 200 µg/ml | $364.00 |