Fmi2 Activators
Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1) is a member of the flamingo subfamily, part of the cadherin superfamily. The cadherin domains are found in cell-adhesion molecules, reflecting the protein's role in establishing and maintaining specific cell-cell connections. These connections are vital for the proper tissue and organ formation during embryonic development and for maintaining tissue integrity throughout life.CELSR1 is characterized by an extensive extracellular region composed of multiple cadherin repeats, EGF-like domains, and Laminin G-like domains, followed by a seven-pass transmembrane region, and ending with a cytoplasmic tail. This structure suggests that CELSR1 functions as an adhesion G-protein-coupled receptor (GPCR), which is a unique combination of cell adhesion and signaling functions.
The protein plays a critical role in the planar cell polarity (PCP) pathway, which is responsible for coordinating the uniform orientation of cells within the plane of a tissue, such as the directional alignment of hair cells in the inner ear or the synchronized arrangement of follicular cells in the skin. CELSR1's function in PCP signaling is essential for various developmental processes, including neural tube closure and the formation of the body's three-dimensional structure.Mutations in the gene encoding CELSR1 have been associated with developmental disorders, particularly neural tube defects such as spina bifida, due to its role in coordinating cell orientation and movement. Additionally, CELSR1 has been implicated in the regulation of neuronal migration and connectivity in the developing brain, and alterations in its function can lead to neurological implications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can lead to activation of PKA, which may phosphorylate substrates that interact with CELSR1, enhancing its cell signaling and adhesive functions. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $166.00 $306.00 $1675.00 | 18 | |
W-7 is a calmodulin antagonist that can influence calcium signaling. Disruption of calmodulin activity may increase calcium influx, potentially enhancing CELSR1-mediated cell adhesion and signaling. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a potent inhibitor of PKC. Inhibition of PKC can shift the balance of cellular signaling pathways, potentially amplifying pathways that activate CELSR1. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. It mimics cAMP and activates PKA, potentially leading to enhanced phosphorylation of proteins that regulate CELSR1 activity. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Inhibiting CaMKII may alter cellular signaling in a way that indirectly enhances CELSR1 signaling. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Gö 6983 is a pan-PKC inhibitor. By inhibiting multiple PKC isoforms, it may indirectly enhance CELSR1 function by modulating the cellular environment and signaling related to cell adhesion. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which increases intracellular cAMP levels. Higher cAMP may activate PKA, potentially enhancing the activity of CELSR1 through phosphorylation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
GF 109203X is a potent PKC inhibitor. By inhibiting PKC, it can indirectly affect cellular signaling mechanisms and potentially enhance CELSR1-related pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium may activate pathways that enhance the function of CELSR1 in cell communication and adhesion. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased cytosolic calcium. This increase in calcium can potentially enhance CELSR1 function by modulating calcium-dependent signaling pathways. | ||||||