FLRT3 Activators
FLRT3 Activators encompass a diverse array of chemical compounds that underpin the functional activity of FLRT3 through discrete signaling pathways. Forskolin, by amplifying cAMP levels, indirectly fosters FLRT3's role in cellular adhesion processes through PKA-mediated phosphorylation cascades that may enhance the stability and function of FLRT3 in the cellular context. In parallel, Sphingosine-1-phosphate, through its receptor-mediated signaling, fortifies FLRT3's contribution to cytoskeletal organization and cellular adhesion by modulating internal signaling networks that intersect with FLRT3's pathways. Epigallocatechin gallate and the PI3K inhibitors LY294002 and Wortmannin attenuate competitive kinase signaling, thus spotlighting FLRT3's involvement in adhesion and migration by preventing the phosphorylation of rival adhesion molecules and reducing AKT-mediated signaling that may oppose FLRT3's cellular functions.
Further supporting the activation ofFLRT3 is the intricate network of cellular mechanics, and the compounds that act as FLRT3 Activators play a pivotal role in the enhancement of its functional dynamics. Forskolin emerges as a key activator, where its role in increasing intracellular cAMP levels leads to the activation of Protein Kinase A (PKA). The subsequent phosphorylation events that ensue are likely to reinforce the stability and interaction of FLRT3 with its binding partners, enhancing its function. Sphingosine-1-phosphate, through receptor-mediated signaling, orchestrates cellular signaling cascades that bolster FLRT3's role in cellular adhesion and cytoskeletal rearrangement. Genistein, by inhibiting tyrosine kinases, potentially clears a path for FLRT3 to assert its function in neurite outgrowth by alleviating the competitive inhibition from tyrosine kinase signaling.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) which can enhance FLRT3 function by PKA activation and subsequent phosphorylation events that may stabilize FLRT3 interaction with its partners. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate acts on its receptors to activate intracellular signaling cascades, including those that can enhance the activity of FLRT3 through cytoskeletal rearrangements and cellular adhesion pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
As a kinase inhibitor, Epigallocatechin gallate may reduce competitive signaling pathways, allowing for FLRT3's functions in cell adhesion and migration to be more prominent through the prevention of phosphorylation on competing adhesion molecules. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor LY294002 diminishes downstream AKT signaling, potentially enhancing FLRT3's role in cell adhesion by reducing opposing signals that inhibit cellular processes where FLRT3 is a key component. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor PD98059 can reduce ERK pathway activity, which might enhance FLRT3's signaling by decreasing the phosphorylation of proteins that negatively regulate FLRT3's partners in cell-cell communication. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), which could enhance FLRT3 activity through the activation of calcium-dependent signaling pathways closely associated with FLRT3 function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC) which can lead to enhanced FLRT3 activity by phosphorylation of FLRT3 or its associated partners, thereby influencing cellular adhesion and motility. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 acts as a mobile ion carrier for Ca2+, potentially enhancing FLRT3 activity by increasing intracellular calcium and activating calcium-dependent signaling pathways that FLRT3 may be part of. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, which may shift signaling towards FLRT3 activation by reducing the competitive phosphorylation of other molecules within the adhesion and cell migration pathways where FLRT3 is involved. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein inhibits tyrosine kinases, which can lead to an enhancement of FLRT3 activity by reducing competitive phosphorylation events and allowing FLRT3-mediated signaling to become more active in processes such as neurite outgrowth. | ||||||