Flotillin-1 Activators
Common Flotillin-1 Activators include, but are not limited to Methyl-β-cyclodextrin CAS 128446-36-6, Lovastatin CAS 75330-75-5, Forskolin CAS 66575-29-9, PMA CAS 16561-29-8 and D-erythro-Sphingosine CAS 123-78-4.
Flotillin-1 is a member of the flotillin family, proteins characterized by their association with membrane microdomains known as lipid rafts. These lipid rafts play significant roles in cellular processes such as signal transduction, endocytosis, and protein trafficking. Flotillin-1, along with its close relative flotillin-2, is predominantly localized in these specialized regions of the cell membrane. The two proteins often co-localize and form hetero-oligomers, suggesting a cooperative function. Flotillin-1's intrinsic structure is distinguished by the presence of a conserved stomatin/prohibitin/flotillin/HflK/C (SPFH) domain, which is crucial for its localization to lipid rafts and its interactions with other proteins. The protein's role in facilitating and modulating signal transduction pathways makes it an essential player in various cellular processes, ranging from cell proliferation to apoptosis.
Flotillin-1 Activators are chemical compounds that elevate or enhance the activity of flotillin-1. The action mechanism of these activators can encompass a broad spectrum: from directly binding to flotillin-1 and altering its conformation to more indirect methods such as modulating pathways that lead to increased flotillin-1 expression or stabilization. By boosting flotillin-1's activity, these activators influence the myriad of processes that this protein is implicated in, particularly those associated with lipid raft dynamics and associated signaling pathways. In research environments, these activators can serve as valuable tools to decipher the nuanced roles of flotillin-1 in cellular physiology. A comprehensive understanding of these activators and their interactions with flotillin-1 can offer a deeper dive into membrane dynamics and its consequent effects on cellular functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Inhibits cholesterol synthesis, potentially affecting lipid rafts and thereby influencing Flotillin-1 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, which can influence membrane dynamics and potentially Flotillin-1 expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, which can influence membrane-associated signaling and possibly Flotillin-1 expression. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
A bioactive lipid that can alter membrane properties, potentially influencing Flotillin-1 expression. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Influences lipid raft dynamics and might play a role in regulating Flotillin-1 levels. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
Induces cholesterol accumulation in cells, potentially affecting lipid raft dynamics and Flotillin-1 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Can modulate gene expression patterns and might influence Flotillin-1 levels via membrane-related mechanisms. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Affects multiple signaling pathways and can alter gene expression, potentially inducing Flotillin-1. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
By modulating cellular lipid metabolism, it might influence lipid raft dynamics and Flotillin-1 expression. | ||||||