FLJ46838 Activators
Chemical activators of FLJ46838 can influence its activity through various intracellular signaling pathways. Phorbol 12-myristate 13-acetate (PMA) activates Protein Kinase C, which is involved in a wide range of cellular processes. Once activated, Protein Kinase C may phosphorylate FLJ46838, altering its conformation or enabling interactions with other molecules, thus changing its activity. Similarly, Forskolin raises intracellular cAMP levels, which in turn activates Protein Kinase A (PKA). PKA can specifically phosphorylate serine and threonine residues on proteins like FLJ46838, if it is indeed a substrate for PKA, thereby modulating its function. Ionomycin facilitates the transport of calcium ions across cell membranes, increasing intracellular calcium concentration, which can activate calcium-dependent kinases. These kinases may phosphorylate FLJ46838, altering its activity state. Another chemical, Okadaic Acid, inhibits protein phosphatases 1 and 2A, leading to sustained protein phosphorylation levels and potentially enhancing the activity of kinases that phosphorylate FLJ46838.
Anisomycin, which inhibits protein synthesis, also activates stress-activated protein kinases such as JNK and p38 MAP kinase. These kinases may target FLJ46838 in response to stress signals. LY294002, by inhibiting phosphoinositide 3-kinases (PI3K), may lead to the activation of alternative signaling pathways that could phosphorylate and activate FLJ46838. Rapamycin, an inhibitor of the mTOR pathway, can also lead to the activation of alternative compensatory pathways, potentially involving kinases that act on FLJ46838. Similarly, 6-Benzylaminopurine activates cyclin-dependent kinases which could interact with FLJ46838 if it plays a role in cell cycle regulation. Thapsigargin, by inhibiting the SERCA pump, disrupts calcium homeostasis, potentially leading to the activation of FLJ46838 through calcium-dependent phosphorylation. Dibutyryl-cAMP, a cAMP analog, activates PKA, which may directly phosphorylate FLJ46838. Phosphatidic Acid, functioning as a second messenger, can activate the mTOR pathway and subsequently affect proteins like FLJ46838. Lastly, Calyculin A, much like Okadaic Acid, inhibits serine/threonine protein phosphatases, possibly maintaining FLJ46838 in a phosphorylated and active state.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
This chemical activates Protein Kinase C which is known to phosphorylate a myriad of proteins. The phosphorylation by PKC can lead to the functional activation of FLJ46838 by changing its conformation or enabling its interaction with other molecules that are essential to its activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP levels, which subsequently activates Protein Kinase A (PKA). PKA is responsible for the phosphorylation of specific serine and threonine residues on target proteins, which can lead to the activation of FLJ46838, assuming FLJ46838 is a substrate for PKA. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as an ionophore that selectively binds to calcium ions and transports them across cell membranes. This increase in intracellular calcium concentration can activate calcium-dependent protein kinases which may phosphorylate and thereby activate FLJ46838. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
As an inhibitor of protein phosphatases 1 and 2A, Okadaic Acid leads to increased levels of phosphorylation on proteins. This inhibition can result in the enhanced activity of kinases and sustained phosphorylation, potentially leading to the activation of FLJ46838. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
This antibiotic functions as a protein synthesis inhibitor but also activates stress-activated protein kinases such as JNK and p38 MAP kinase. The activation of these kinases can lead to the phosphorylation and activation of FLJ46838 in stress response pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K), which leads to a subsequent decrease in Akt phosphorylation. This can result in the activation of upstream or alternative signaling pathways that could activate FLJ46838 as part of a compensatory cellular response. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which can lead to the activation of upstream kinases or alternative compensatory pathways that could include kinases that phosphorylate and activate FLJ46838. | ||||||
6-Benzylaminopurine | 1214-39-7 | sc-202428 sc-202428A | 1 g 5 g | $20.00 $51.00 | ||
This synthetic cytokinin activates cyclin-dependent kinases, which could phosphorylate and activate FLJ46838 if it is involved in cell cycle regulation and is a substrate for these kinases. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that disrupts calcium storage and increases cytosolic calcium concentration, leading to the activation of calcium-dependent kinases. These kinases could then phosphorylate and activate FLJ46838. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
As a cAMP analog, Dibutyryl-cAMP can diffuse into cells and directly activate Protein Kinase A (PKA). PKA then phosphorylates target proteins, which could include FLJ46838, leading to its activation. | ||||||