FLJ13231 Activators
Activators of FLJ13231 (ciliogenesis and planar polarity effector complex subunit 1) function through various mechanisms to enhance the formation and function of cilia, a process essential for cellular signaling and tissue homeostasis. Compounds that increase intracellular cAMP levels, such as adenylyl cyclase activators and phosphodiesterase inhibitors, can activate protein kinase A, leading to phosphorylation events that promote ciliogenesis and, in turn, potentially augment the role of FLJ13231 in this process. Similarly, agents that modulate the actin cytoskeleton influence cell shape and motility, factors critical for the establishment of planar cell polarity and ciliogenesis, thereby affecting the functional activity of FLJ13231.
Additionally, molecules that interact with cellular differentiation pathways, such as retinoic acid receptors and components of the Wnt signaling pathway, can alter gene expression patterns crucial for ciliogenesis, implicating FLJ13231 in these pathways. Inhibitors of autophagy and mTOR signaling, as well as compounds that affect the hedgehog signaling pathway, may also induce ciliary formation and function, indirectly impacting FLJ13231's activity. Other chemicals can modulate essential signaling events which are crucial for ciliogenesis maintenance, where FLJ13231 is presumed to play a role. Conversely, agents that can induce cellular quiescence or disrupt cellular metabolism may indirectly trigger the initiation of ciliogenesis, potentially enhancing the activity of FLJ13231 within this context.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Non-selective phosphodiesterase inhibitor, prevents the breakdown of cAMP, indirectly enhancing the cAMP signaling cascade and potentially upregulating the activity of ciliogenesis and planar polarity effector complex subunit 1 through PKA activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Selective phosphodiesterase 4 inhibitor, increases intracellular cAMP by preventing its degradation, thus potentially enhancing the cAMP/PKA pathway that could activate ciliogenesis and planar polarity effector complex subunit 1. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
Precursor of nitric oxide (NO) synthesis. NO can activate guanylyl cyclase and increase cGMP, which may interact with the cAMP pathway and affect the activity of ciliogenesis and planar polarity effector complex subunit 1 indirectly. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor, which could lead to actin cytoskeleton rearrangement, affecting the processes associated with ciliogenesis, potentially activating ciliogenesis and planar polarity effector complex subunit 1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β, thus potentially enhancing the Wnt signaling pathway, which can indirectly lead to the activation of ciliogenesis-related proteins such as ciliogenesis and planar polarity effector complex subunit 1. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
GSK-3β inhibitor, possibly promoting the Wnt/β-catenin signaling pathway which can affect the activity of ciliogenesis-associated proteins, including ciliogenesis and planar polarity effector complex subunit 1. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
β-adrenergic receptor agonist that increases cAMP levels, potentially enhancing the PKA signaling pathway and indirectly activating ciliogenesis and planar polarity effector complex subunit 1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Influences cellular differentiation and development processes, which may indirectly upregulate the activity of ciliogenesis-related proteins such as ciliogenesis and planar polarity effector complex subunit 1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Polyphenol found in green tea, which has been shown to influence various signaling pathways and might indirectly enhance the activity of proteins involved in ciliogenesis, including ciliogenesis and planar polarity effector complex subunit 1. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A form of vitamin B3 that serves as a precursor for NAD+, which is essential for various metabolic processes and may indirectly affect the activity of proteins involved in ciliogenesis, such as ciliogenesis and planar polarity effector complex subunit 1. | ||||||