FIZ Activators
FIZ Activators are a diverse group of chemical compounds that have complex mechanisms of action, indirectly leading to the functional enhancement of the FIZ protein through various intracellular signaling pathways. Forskolin, for instance, by increasing cAMP levels, activates PKA, which could phosphorylate and change the activity of proteins that directly interact with or regulate FIZ. EGCG, through its effects on kinase signaling, may inhibit kinases that negatively regulate FIZ, leading to increased FIZ activity. Ionomycin, by raising intracellular calcium levels, and PMA, as an activator of PKC, both have the potential to modify the phosphorylation status of proteins in pathways that regulate FIZ activity. Similarly, sphingosine-1-phosphate alters lipid signaling, which could impact FIZ's lipid environment or signaling context, potentially enhancing its activity.
Furthermore, inhibitors of key signaling enzymes such as LY294002 and Wortmannin, which target PI3K, as well as U0126 and SB203580, which target MEK and p38 MAPK respectively, can alter the regulatory landscape of cellular pathways to favor the activation of FIZ. Through the inhibition of these kinases, these compounds can shift the signaling balance, leading to enhanced activity of FIZ either by reducing negative regulation or by promoting pathways that facilitate FIZ function. Thapsigargin, by disrupting calcium homeostasis, and Genistein, through tyrosine kinase inhibition, also contribute to the activation of signaling pathways that can ultimately result in the upregulation of FIZ activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which indirectly enhances the activity of FIZ by activating cAMP-dependent protein kinase A (PKA). PKA phosphorylation can lead to changes in the activity of proteins that directly interact with or regulate FIZ. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a potent antioxidant that can modulate kinase signaling pathways. This modulation can indirectly increase the activity of FIZ by inhibiting kinases that may negatively regulate FIZ activity or its interacting partners. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, indirectly enhancing the activity of FIZ by activating calcium-dependent signaling pathways that may interact with or regulate FIZ. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the phosphorylation of proteins that interact with or regulate the function of FIZ, thereby indirectly increasing its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate engages in lipid signaling that can modulate various signaling pathways and potentially enhance the activity of FIZ by affecting its lipid environment or signaling context. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter signaling dynamics, potentially enhancing the activity of FIZ by shifting the balance of intracellular signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that can indirectly enhance the activity of FIZ by affecting the PI3K/AKT pathway and altering the regulation of proteins that interact with FIZ. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that can shift signaling pathways towards those that enhance the activity of FIZ by reducing the activity of the MAPK/ERK pathway and affecting downstream regulatory proteins. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that can indirectly enhance FIZ activity by modulating stress-activated protein kinase pathways and altering the cellular response in a way that could enhance FIZ function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by blocking the SERCA pump, which can lead to the activation of calcium-dependent signaling pathways that indirectly enhance the activity of FIZ. | ||||||