FIBIN Activators
FIBIN can exert their effects through various signaling pathways that ultimately lead to the modulation of FIBIN activity. Forskolin acts directly on adenylyl cyclase, which catalyzes the conversion of ATP to cAMP, a secondary messenger that can activate protein kinase A (PKA). PKA then goes on to phosphorylate numerous proteins, which may include FIBIN, thereby regulating its function. Similarly, Isoproterenol, by engaging beta-adrenergic receptors, leads to the activation of G proteins and the subsequent activation of adenylyl cyclase, increasing cAMP levels and activating PKA, which may influence FIBIN activity. Prostaglandin E2 (PGE2) operates through its own G-protein coupled receptors (GPCRs) to increase cAMP, and thereby PKA activity, which can modulate the activity of FIBIN. Dibutyryl-cAMP, a cAMP analog, bypasses cell surface receptors and directly activates PKA, offering another pathway to alter FIBIN's activity.
In another signaling axis, Anisomycin, through its inhibition of protein synthesis, inadvertently activates stress-activated protein kinases such as JNK, which may phosphorylate FIBIN if it is among their substrates. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can also phosphorylate proteins within FIBIN's signaling pathways. Ionomycin raises intracellular calcium levels, which can activate calmodulin-dependent kinases (CaMK), possibly affecting FIBIN activity. Epidermal Growth Factor (EGF) binds to its receptor to initiate a cascade that can lead to the activation of proteins in FIBIN's network. Insulin triggers receptor-mediated activation of the PI3K/Akt pathway, which can phosphorylate and modulate proteins that interact with FIBIN. Vascular Endothelial Growth Factor (VEGF) engages its receptors to start the MAPK/ERK signaling, possibly leading to the activation of FIBIN-associated proteins. Bradykinin, through B2 receptors, increases intracellular calcium and activates kinases that may influence FIBIN's regulatory pathways. Lastly, Histamine, via the H1 receptor, can also elevate intracellular calcium, activating kinases that may phosphorylate proteins in FIBIN's signaling network.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate and thereby activate proteins involved in various signaling pathways, including those associated with FIBIN. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, binds to beta-adrenergic receptors, leading to G protein activation and subsequent activation of adenylyl cyclase. This increases cAMP levels, which through PKA, can activate downstream proteins potentially including FIBIN. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) interacts with its G-protein coupled receptors (GPCRs), leading to increased intracellular cAMP levels via adenylyl cyclase activation. This boost in cAMP may activate PKA, thereby influencing the activity of proteins such as FIBIN. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases (SAPKs) such as JNK. JNK activation can lead to the phosphorylation and activation of target proteins, potentially including FIBIN if it is a substrate for these kinases. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). Activated PKC may phosphorylate and activate proteins within the same signaling pathways as FIBIN, thereby enhancing its functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinases (CaMK), which may contribute to the activation of proteins in pathways that include FIBIN. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin engages its receptor leading to receptor autophosphorylation and the activation of the PI3K/Akt signaling pathway. Akt can phosphorylate and activate various proteins that may interact with or regulate FIBIN's activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. PKA can then phosphorylate and activate proteins in the same pathways as FIBIN, potentially enhancing FIBIN's activity. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin binds to B2 receptors, which are GPCRs, leading to increased intracellular calcium levels and the potential activation of protein kinases that can phosphorylate and activate proteins in the same pathways as FIBIN. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its H1 receptor, can increase intracellular calcium and activate several kinases. These kinases could phosphorylate proteins that are involved in the same pathways as FIBIN, thus enhancing FIBIN's activity. | ||||||