FEM-1 Inhibitors
Chemical inhibitors of FEM-1 function through various mechanisms to modulate cellular signaling pathways. Palmitoyl-DL-carnitine disrupts fatty acid metabolism, which is essential for the energy-dependent processes of cells expressing FEM-1, thereby inhibiting its function. Similarly, LY294002 and Wortmannin are potent inhibitors of PI3K, affecting the downstream signaling of FEM-1 by preventing AKT phosphorylation. This action directly impacts FEM-1's role within these signaling cascades. U0126 and PD98059, both MEK inhibitors, impede the MAPK/ERK pathway, which FEM-1 may utilize, thereby influencing its function in cell cycle regulation and differentiation. SB203580 targets p38 MAP kinase, likely affecting stress response pathways where FEM-1 is active, while SP600125 inhibits JNK signaling, which intersects with FEM-1 pathways involved in stress response and apoptosis.
Complementing these inhibitors, MG132 and Bortezomib both act on proteasome-mediated degradation. MG132 prevents the degradation of ubiquitinated proteins, while Bortezomib inhibits the 26S proteasome, leading to the accumulation of polyubiquitinated proteins. Both mechanisms can influence the turnover of proteins regulated by FEM-1. Dasatinib, as a Src family kinase inhibitor, acts on Src kinase-related pathways and affects FEM-1 signaling where Src kinases are implicated. Rapamycin, through its inhibition of mTOR, also impacts the PI3K/AKT pathway, leading to a decrease in processes such as protein synthesis and cell growth where FEM-1 is believed to play a role. Lastly, Trichostatin A, by inhibiting histone deacetylases, can alter gene expression and chromatin structure, which may change the expression patterns of proteins in the FEM-1 pathway, influencing its functional role in the cell. These chemical inhibitors collectively target different aspects of the signaling pathways and degradation processes to inhibit the function of FEM-1 within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 acts as an inhibitor of PI3K, a kinase that signals downstream of FEM-1 in certain cellular contexts, thus leading to the inhibition of AKT phosphorylation and subsequent downstream signaling that may be required for FEM-1 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, which is part of the MAPK/ERK pathway that can be involved in the signaling pathways where FEM-1 functions, leading to decreased ERK phosphorylation and potentially inhibiting FEM-1 mediated signaling events. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase, which could be involved in stress response pathways where FEM-1 may play a role, leading to the inhibition of cellular processes that FEM-1 may influence. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can prevent the degradation of ubiquitinated proteins; since FEM-1 is known to be involved in ubiquitin-mediated processes, MG132 could inhibit the degradation pathway of proteins regulated by FEM-1. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor which could inhibit the Src kinase-related pathways that may be involved in the regulation of FEM-1 signaling, thereby inhibiting FEM-1 function in processes where Src kinases are implicated. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib inhibits the 26S proteasome, which could lead to the accumulation of polyubiquitinated proteins and could inhibit the proteasome-mediated degradation process where FEM-1 may be involved. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK signaling, which may intersect with FEM-1 mediated pathways, particularly in stress response and apoptosis, leading to the inhibition of FEM-1 function in these cellular responses. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor like LY294002; it can inhibit the PI3K-dependent pathways that FEM-1 may utilize, thereby potentially inhibiting the FEM-1’s role in these signaling cascades. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the PI3K/AKT pathway; inhibition of mTOR can lead to a decrease in cellular processes like protein synthesis and cell growth where FEM-1 might be involved. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDAC), which can alter chromatin structure and gene expression; FEM-1, being a part of regulatory processes, could be inhibited due to changes in expression patterns of proteins in its pathway. | ||||||