FDXACB1 Activators
FDXACB1, encoding a protein with a ferredoxin-fold anticodon-binding domain within a subset of phenylalanyl tRNA synthetases, plays a crucial role in translation processes. The activation of FDXACB1 involves both direct and indirect mechanisms, with various chemicals influencing its expression and function. Direct activators, such as 4-phenylbutyric acid (4-PBA) and celastrol, act as molecular chaperones and antioxidants, respectively, mitigating protein misfolding and oxidative stress. These chemicals contribute to improved protein folding, potentially enhancing FDXACB1 expression and function in translation processes.
Indirect activators, including tunicamycin and geldanamycin, influence cellular pathways such as N-glycosylation and HSP90-mediated protein folding, indirectly up-regulating FDXACB1. Additionally, compounds like A769662 and bortezomib activate stress response pathways, leading to increased FDXACB1 expression in response to metabolic stress and proteasomal inhibition. Understanding FDXACB1's activation sheds light on its role in phenylalanyl tRNA synthetases and translation processes. The interconnected regulatory networks, including unfolded protein response, endoplasmic reticulum stress, and cellular homeostasis, showcase the sophisticated nature of FDXACB1's regulation within cellular contexts. Further exploration into these mechanisms will contribute to a comprehensive understanding of FDXACB1's role in cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin, an N-glycosylation inhibitor, indirectly activates FDXACB1. Inhibiting N-glycosylation disrupts protein folding, inducing unfolded protein response (UPR) pathways. FDXACB1, associated with phenylalanyl tRNA synthetases, is up-regulated as part of UPR mechanisms, enhancing its expression and function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132, a proteasome inhibitor, indirectly activates FDXACB1. Inhibition of proteasomal degradation stabilizes proteins, including FDXACB1. This leads to increased levels of FDXACB1, contributing to enhanced phenylalanyl tRNA synthetase activity and the protein's role in translation. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal, an eIF2α dephosphorylation inhibitor, indirectly activates FDXACB1. By inhibiting eIF2α dephosphorylation, salubrinal induces endoplasmic reticulum stress and activates the integrated stress response. FDXACB1, associated with translation processes, is up-regulated as part of this stress response, enhancing its expression and function. | ||||||
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
4-Phenylbutyric acid (4-PBA), a chemical chaperone, indirectly activates FDXACB1. Acting as a molecular chaperone, 4-PBA mitigates protein misfolding and endoplasmic reticulum stress. FDXACB1, associated with phenylalanyl tRNA synthetases, benefits from improved protein folding, leading to increased expression and function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin, an ER calcium pump inhibitor, indirectly activates FDXACB1. By disrupting calcium homeostasis, thapsigargin induces endoplasmic reticulum stress and the unfolded protein response. FDXACB1, associated with phenylalanyl tRNA synthetases, is up-regulated as part of this stress response, enhancing its expression and function. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin, a HSP90 inhibitor, indirectly activates FDXACB1. Inhibition of HSP90 destabilizes client proteins, leading to their degradation. FDXACB1, associated with phenylalanyl tRNA synthetases, may be stabilized in response to protein unfolding, contributing to increased expression and function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187, a calcium ionophore, indirectly activates FDXACB1. By elevating intracellular calcium levels, A23187 induces endoplasmic reticulum stress and the unfolded protein response. FDXACB1, associated with phenylalanyl tRNA synthetases, is up-regulated as part of this stress response, leading to increased expression and function. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium (meta)arsenite, an oxidative stress inducer, indirectly activates FDXACB1. By inducing oxidative stress, sodium arsenite activates stress response pathways, including the unfolded protein response. FDXACB1, associated with phenylalanyl tRNA synthetases, is up-regulated in response to oxidative stress, enhancing its expression and function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A, a vesicular transport inhibitor, indirectly activates FDXACB1. Inhibition of vesicular transport disrupts protein trafficking, inducing endoplasmic reticulum stress and the unfolded protein response. FDXACB1, associated with phenylalanyl tRNA synthetases, is up-regulated as part of this stress response, contributing to increased expression and function. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662, an AMP-activated protein kinase (AMPK) activator, indirectly activates FDXACB1. By activating AMPK, A769662 induces metabolic stress and the unfolded protein response. FDXACB1, associated with phenylalanyl tRNA synthetases, is up-regulated as part of this stress response, leading to increased expression and function. | ||||||