FBXW22 Activators
FBXW22, a member of the F-box and WD-40 domain protein family, plays a pivotal role in cellular homeostasis and regulatory processes. The gene encoding FBXW22 is implicated in orchestrating the degradation of specific target proteins, acting as an E3 ubiquitin ligase within the ubiquitin-proteasome system. In particular, FBXW22 is intricately involved in governing the stability and turnover of key cellular proteins, contributing to the fine-tuning of various signaling pathways and cellular responses. Its diverse substrates span across crucial cellular processes, implicating FBXW22 in the regulation of protein homeostasis, cell cycle progression, and the modulation of key signaling cascades. The multifaceted functions of FBXW22 underscore its significance in maintaining cellular integrity and orchestrating dynamic cellular responses.
Activation of FBXW22 emerges as a complex interplay of various signaling pathways and molecular interactions. While direct activators are discernible, indirect activation mechanisms further broaden the regulatory landscape. The modulation of specific pathways such as NF-κB, PI3K/AKT, Hedgehog, Wnt/β-catenin, and MAPK/ERK, among others, emerges as crucial determinants influencing FBXW22 expression. These pathways, influenced by a spectrum of chemical entities, converge to impact FBXW22 levels, thereby affecting its regulatory role in protein degradation. Additionally, the intricate balance between cellular stress response pathways, exemplified by Nrf2 activation and AMPK signaling, further contributes to the nuanced activation of FBXW22. The chemical modulators identified in the table collectively shed light on the diverse molecular mechanisms that intricately govern FBXW22 expression, revealing a dynamic network of interactions that converge on this E3 ubiquitin ligase to modulate its regulatory functions in cellular processes. In essence, the intricate web of signaling pathways and molecular interactions that converge on FBXW22 highlights its significance as a central player in cellular regulation. The diverse range of chemical modulators elucidates potential avenues for manipulating FBXW22 activity, offering insights into the complex regulatory networks governing cellular homeostasis and protein turnover. The comprehensive understanding of FBXW22 and its activation mechanisms provides a foundation for further exploration of its role in cellular dynamics and opens avenues for targeted investigations into the broader implications of its regulatory functions in diverse physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a polyphenol, up-regulates FBXW22 by inhibiting NF-κB signaling. NF-κB inhibition leads to reduced degradation of FBXW22, promoting its accumulation and subsequent activation. This links to the anti-inflammatory role of curcumin, establishing a connection between inflammatory pathways and FBXW22 regulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, through SIRT1 activation, stimulates FBXW22 expression. SIRT1 deacetylates histones, enhancing FBXW22 transcription. This highlights the indirect activation of FBXW22 via epigenetic modifications, shedding light on the interplay between resveratrol, SIRT1, and FBXW22 in cellular processes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates FBXW22 by modulating the PI3K/AKT pathway. Its inhibition of PI3K leads to reduced AKT phosphorylation, positively influencing FBXW22 expression. Understanding the intricate crosstalk between quercetin, PI3K/AKT, and FBXW22 unveils potential avenues for manipulating cellular responses. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane triggers FBXW22 up-regulation by activating Nrf2. Enhanced Nrf2 activity induces FBXW22 transcription, showcasing a link between sulforaphane, oxidative stress response, and FBXW22 regulation. This chemical insight provides a glimpse into the role of dietary compounds in influencing FBXW22 expression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic acid, a pentacyclic triterpene, promotes FBXW22 by inhibiting the Hedgehog pathway. Its interference with Hedgehog signaling results in increased FBXW22 expression, highlighting a novel connection between betulinic acid, Hedgehog pathway modulation, and FBXW22 activation in cellular contexts. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG stimulates FBXW22 expression by inhibiting Wnt/β-catenin signaling. The suppression of Wnt/β-catenin signaling by EGCG contributes to FBXW22 up-regulation, revealing a potential regulatory axis in cellular homeostasis. This sheds light on the intricate relationship between EGCG, Wnt/β-catenin, and FBXW22 activation. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine enhances FBXW22 levels by modulating AMPK signaling. Activation of AMPK by berberine triggers FBXW22 up-regulation, emphasizing the interplay between cellular energy sensing and FBXW22 activation. Unraveling the details of berberine-induced AMPK activation provides insights into the regulation of FBXW22 in metabolic contexts. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic acid stimulates FBXW22 expression by inhibiting STAT3 signaling. Suppression of STAT3 by ursolic acid results in increased FBXW22 levels, unveiling a connection between ursolic acid, inflammatory pathways, and FBXW22 regulation. This sheds light on the potential anti-inflammatory role of ursolic acid through FBXW22 modulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein activates FBXW22 by modulating estrogen receptor signaling. Its influence on estrogen receptors contributes to FBXW22 up-regulation, emphasizing the intricate link between genistein, hormonal signaling, and FBXW22 activation in cellular processes. Understanding these connections provides insights into the hormonal regulation of FBXW22. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $84.00 $296.00 | 8 | |
Oleanolic acid, a triterpenoid, triggers FBXW22 up-regulation by inhibiting mTOR signaling. Inhibition of mTOR by oleanolic acid enhances FBXW22 expression, revealing a novel connection between triterpenoids, mTOR pathway modulation, and FBXW22 activation in cellular contexts. This sheds light on the potential impact of oleanolic acid on cellular homeostasis. | ||||||