Date published: 2025-11-24

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FBXO40 Inhibitors

FBXO40 is a component of the Skp1-Cullin 1-F-box (SCF) E3 ubiquitin ligase complex, a crucial machinery responsible for ubiquitinating specific target proteins and marking them for degradation by the proteasome. In the context of the SCF complex, FBXO40 acts as the F-box protein, which provides substrate specificity by recognizing and binding to specific target proteins. The binding of FBXO40 to its target proteins leads to their ubiquitination, ultimately regulating their stability and cellular levels. Inhibitors of FBXO40 disrupt the interaction between FBXO40 and its specific substrate proteins, thus interfering with the ubiquitination and subsequent degradation of these substrates. The precise mechanisms by which FBXO40 inhibitors achieve this interference are areas of ongoing research. Understanding the functions and regulatory roles of FBXO40 within the SCF E3 ubiquitin ligase complex can provide valuable insights into the intricate machinery governing protein turnover and degradation in cells, shedding light on the broader mechanisms that control cellular processes and homeostasis.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

A proteasome inhibitor that can indirectly influence the level of proteins involved in transcription regulation, potentially affecting FBXO40 expression.

Epoxomicin

134381-21-8sc-201298C
sc-201298
sc-201298A
sc-201298B
50 µg
100 µg
250 µg
500 µg
$134.00
$215.00
$440.00
$496.00
19
(2)

A selective proteasome inhibitor, which may stabilize transcription factors and thus could impact the expression of genes like FBXO40.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Another proteasome inhibitor that can affect NF-κB signaling, which may indirectly lead to altered expression of FBXO40.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

Inhibits eukaryotic translation elongation, which could reduce overall protein synthesis, including that of FBXO40.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Intercalates into DNA and inhibits RNA polymerase action, potentially downregulating the transcription of FBXO40.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

An mTOR inhibitor that can broadly affect protein synthesis and could influence the expression of FBXO40.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

A PI3K inhibitor that might disrupt signaling pathways, potentially leading to altered FBXO40 expression.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Another PI3K inhibitor that can affect various signaling pathways, which may indirectly change FBXO40 expression.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

A histone deacetylase inhibitor that can alter gene expression patterns, potentially affecting the expression of FBXO40.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

A DNA methyltransferase inhibitor that can cause demethylation of DNA and alter gene expression, possibly including FBXO40.