Date published: 2026-5-24

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FBL20 Inhibitors

Chemical inhibitors of FBL20 can interact with and modulate the protein's activity through various mechanisms, primarily by stabilizing proteins that directly or indirectly regulate FBL20 function. Proteasome inhibitors such as MG132, Bortezomib, Epoxomicin, Lactacystin, and Withaferin A function by preventing the degradation of regulatory proteins that interact with FBL20. This inhibition of proteolytic activity leads to an accumulation of these regulatory proteins within the cell, which in turn inhibits the function of FBL20 by disrupting its normal regulatory processes and interactions. The stabilization of such proteins can inhibit the functional activity of FBL20 by preventing the normal proteolytic processing that FBL20 might require for its activity or by altering its substrate interactions, thus leading to functional inhibition. Furthermore, inhibitors that target a range of proteases, such as Leupeptin, E-64, Chymostatin, Aprotinin, Pepstatin A, and ALLN, can also indirectly inhibit FBL20. These inhibitors work by preventing the breakdown of proteins that regulate the activity of FBL20, thus affecting its functional state. By inhibiting lysosomal proteases, cysteine proteases, chymotrypsin-like proteases, and aspartyl proteases, these chemicals lead to the accumulation of proteins that can inhibit the activity of FBL20 by interfering with its normal turnover and processing. Additionally, Omeprazole, although primarily a proton pump inhibitor, can alter the cellular environment in such a way that affects the stability and interactions of proteins controlling FBL20 activity, indirectly leading to its functional inhibition.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

MG132 is a proteasome inhibitor that can indirectly inhibit FBL20 by preventing the degradation of proteins that regulate its activity. By stabilizing these regulatory proteins, MG132 can lead to the functional inhibition of FBL20.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

Bortezomib is another proteasome inhibitor that can lead to the accumulation of FBL20 regulatory proteins, which can inhibit its function by potentially altering its interaction with substrates or other proteins involved in its signaling pathway.

Epoxomicin

134381-21-8sc-201298C
sc-201298
sc-201298A
sc-201298B
50 µg
100 µg
250 µg
500 µg
$137.00
$219.00
$449.00
$506.00
19
(2)

Epoxomicin selectively inhibits the proteasome, thereby stabilizing proteins that regulate FBL20 activity. This can result in an inhibition of FBL20 function due to the disruption of its normal regulatory degradation processes.

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
$188.00
$575.00
60
(2)

Lactacystin is a proteasome inhibitor that can indirectly inhibit FBL20 by preventing the proteasomal degradation of proteins that regulate FBL20, thus affecting its activity.

Leupeptin hemisulfate

103476-89-7sc-295358
sc-295358A
sc-295358D
sc-295358E
sc-295358B
sc-295358C
5 mg
25 mg
50 mg
100 mg
500 mg
10 mg
$73.00
$148.00
$316.00
$499.00
$1427.00
$101.00
19
(3)

Leupeptin inhibits lysosomal proteases, which can lead to the accumulation of regulatory proteins of FBL20 within the cell, thus potentially inhibiting FBL20 function by interfering with its normal protein turnover.

E-64

66701-25-5sc-201276
sc-201276A
sc-201276B
5 mg
25 mg
250 mg
$281.00
$947.00
$1574.00
14
(0)

E-64 is a cysteine protease inhibitor that can indirectly affect FBL20 by stabilizing its regulatory proteins. This can inhibit the functional activity of FBL20 by preventing the normal proteolytic processing that is required for its function.

Chymostatin

9076-44-2sc-202541
sc-202541A
sc-202541B
sc-202541C
sc-202541D
5 mg
10 mg
25 mg
50 mg
100 mg
$156.00
$260.00
$640.00
$1186.00
$2270.00
3
(1)

Chymostatin inhibits chymotrypsin-like proteases, which can result in the accumulation of proteins that regulate the function of FBL20, leading to its functional inhibition.

Aprotinin

9087-70-1sc-3595
sc-3595A
sc-3595B
10 mg
100 mg
1 g
$112.00
$408.00
$3000.00
51
(2)

Aprotinin is a protease inhibitor that can lead to the accumulation of proteins involved in the regulation of FBL20, potentially inhibiting its activity by disrupting its normal protein degradation pathway.

Omeprazole

73590-58-6sc-202265
50 mg
$67.00
4
(1)

Omeprazole, while known as a proton pump inhibitor, can alter the cellular environment, potentially leading to the stabilization of proteins that regulate FBL20 and indirectly inhibit its function through effects on cellular signaling and protein turnover.

Withaferin A

5119-48-2sc-200381
sc-200381A
sc-200381B
sc-200381C
1 mg
10 mg
100 mg
1 g
$130.00
$583.00
$4172.00
$20506.00
20
(1)

Withaferin A can interfere with the proteasomal pathway, leading to the accumulation of proteins that regulate FBL20, which can inhibit the functional activity of FBL20 by altering its normal degradation and regulatory processes.