Date published: 2025-10-23

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Fatty Acid Synthase Inhibitors

Fatty Acid Synthase (FAS) is a multi-enzyme protein responsible for the biosynthesis of long-chain fatty acids, primarily palmitate, from acetyl-CoA and malonyl-CoA precursors. This process, known as fatty acid synthesis, is a cytosolic pathway that involves a series of enzymatic reactions, and FAS plays a pivotal role in orchestrating these steps. In many organisms, including humans, FAS operates as a large dimeric protein with each monomer containing all the required enzymatic domains for fatty acid synthesis. The synthesis of fatty acids is a fundamental aspect of cellular metabolism, ensuring the availability of fatty acids for various cellular functions, including membrane structure, energy storage, and signaling molecule synthesis. Fatty Acid Synthase Inhibitors are chemical entities designed to target and impede the function of the FAS enzyme. These inhibitors can act by binding to specific domains within the enzyme, thereby obstructing the enzymatic reactions necessary for fatty acid synthesis. Given the central role of FAS in lipid metabolism, inhibiting its function can have profound effects on cellular lipid composition and overall metabolic equilibrium. The specificity and mechanism of action of these inhibitors can vary, with some targeting the early stages of fatty acid synthesis and others affecting the later stages.

Items 1 to 10 of 14 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

BML-275

866405-64-3sc-200689
sc-200689A
5 mg
25 mg
$94.00
$348.00
69
(1)

BML-275 is a selective inhibitor of fatty acid synthase, exhibiting unique binding interactions that disrupt the enzyme's catalytic activity. Its structure allows for specific interactions with the active site, altering the enzyme's conformation and inhibiting substrate access. The compound's kinetic profile reveals a competitive inhibition mechanism, impacting lipid biosynthesis pathways. Additionally, BML-275's hydrophobic characteristics enhance its affinity for lipid membranes, influencing cellular uptake and distribution.

Cerulenin (synthetic)

17397-89-6sc-200827
sc-200827A
sc-200827B
5 mg
10 mg
50 mg
$158.00
$306.00
$1186.00
9
(1)

A natural product that specifically inhibits FASN activity, leading to reduced fatty acid synthesis.

Kaempferol

520-18-3sc-202679
sc-202679A
sc-202679B
25 mg
100 mg
1 g
$97.00
$212.00
$500.00
11
(1)

Kaempferol acts as a modulator of fatty acid synthase, engaging in unique non-covalent interactions that stabilize the enzyme's structure. Its presence can alter the enzyme's allosteric sites, leading to changes in reaction kinetics and substrate affinity. This flavonoid influences lipid metabolism by affecting the enzyme's regulatory pathways, potentially shifting the balance of fatty acid production. Its hydrophilic and lipophilic properties facilitate diverse interactions within cellular environments.

C75 (racemic)

191282-48-1sc-202511
sc-202511A
sc-202511B
1 mg
5 mg
10 mg
$71.00
$202.00
$284.00
9
(1)

A synthetic compound that inhibits FASN and induces apoptosis in cancer cells.

Quercetin Dihydrate

6151-25-3sc-203225
sc-203225A
5 g
25 g
$35.00
$60.00
1
(1)

Quercetin Dihydrate functions as a modulator of fatty acid synthase, exhibiting distinct binding affinities that influence enzyme conformation. It interacts with specific amino acid residues, enhancing or inhibiting catalytic activity through allosteric modulation. This flavonoid can impact lipid biosynthesis by altering metabolic flux, while its dual solubility characteristics enable it to navigate complex cellular environments, facilitating diverse biochemical interactions.

Luteolin

491-70-3sc-203119
sc-203119A
sc-203119B
sc-203119C
sc-203119D
5 mg
50 mg
500 mg
5 g
500 g
$26.00
$50.00
$99.00
$150.00
$1887.00
40
(1)

A flavonoid that can suppress FASN expression and influence lipid metabolism.

Lipase Inhibitor, THL

96829-58-2sc-203108
50 mg
$51.00
7
(1)

Lipase Inhibitor, THL inhibits FASN, impacting lipid metabolism.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

Epigallocatechin gallate, a green tea polyphenol, has been shown to inhibit FASN expression.

Pyrazinamide

98-96-4sc-205824
sc-205824A
sc-205824B
sc-205824C
sc-205824D
sc-205824E
10 g
25 g
100 g
250 g
1 kg
5 kg
$48.00
$66.00
$87.00
$148.00
$474.00
$2231.00
(1)

Pyrazinamide acts as a unique inhibitor of fatty acid synthase, engaging in specific interactions with the enzyme's active site. Its structural features allow it to disrupt the enzyme's catalytic cycle, leading to altered reaction kinetics. By stabilizing certain conformations, it can modulate the accessibility of substrates, thereby influencing lipid metabolism pathways. Additionally, its hydrophilic nature aids in solubility, promoting effective distribution within cellular compartments.

Triclosan

3380-34-5sc-220326
sc-220326A
10 g
100 g
$138.00
$400.00
(1)

An antibacterial agent, triclosan also inhibits FASN.