FAT2 Activators
FAT2 Activators encompass a range of compounds that can indirectly influence the activity or expression of the FAT2 protein. These activators do not directly bind or interact with FAT2 but instead modulate various cellular signaling pathways and processes that can lead to the upregulation of FAT2 activity or expression levels. The pathways influenced by these activators include the cAMP signaling cascade, protein kinase C (PKC) pathway, Wnt signaling, and epigenetic regulation mechanisms, among others.
The modulation of cAMP levels by forskolin and IBMX, or the use of the cAMP analog dibutyryl-cAMP, can lead to changes in FAT2 through the activation of protein kinase A (PKA) and subsequent phosphorylation events. Similarly, the activation of PKC by compounds like PMA can result in altered phosphorylation states of proteins within the same cellular context as FAT2, thereby affecting its function. Compounds like retinoic acid and sodium butyrate work by influencing gene expression, which can result in increased levels of FAT2 protein. Lastly, genistein and resveratrol exert their effects through the inhibition of kinase activities and modulation of sirtuin functions, respectively, leading to alterations in signaling pathways that intersect with the regulation of FAT2.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels, which can modulate FAT2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Inhibits phosphodiesterases, increasing cAMP levels, possibly affecting FAT2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Affects signal transduction pathways, which may influence FAT2 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C, which could modulate FAT2 by phosphorylation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Influences cell differentiation pathways that can alter FAT2 expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
A cAMP analog that bypasses receptor-mediated activation, may affect FAT2. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor, can modulate signaling pathways involving FAT2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Affects glycogen synthase kinase-3 (GSK-3) activity, potentially affecting FAT2. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor, can influence gene expression, including FAT2. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Impacts sirtuin function and may modulate signaling pathways linked to FAT2. | ||||||