FAM9B Activators
FAM9B activators constitute a spectrum of chemical entities that serve to indirectly potentiate the functional activity of FAM9B through various cellular and molecular mechanisms. Epigallocatechin gallate (EGCG) and Forskolin are prime examples; EGCG's inhibitory action on DNA methyltransferases may induce hypomethylation of the FAM9B gene promoter, thereby upregulating FAM9B expression. Concurrently, Forskolin's elevation of intracellular cAMP levels activates PKA, which is capable of phosphorylating substrates that bolster the activity of FAM9B. Another activator, Ionomycin, exerts its effects by increasing intracellular calcium, which in turn activates calmodulin-dependent kinases, potentially culminating in the phosphorylation of proteins that work in concert with FAM9B to enhance its function. Similarly, PMA, through the activation of PKC, can initiate phosphorylation cascades that eventually amplify the activity of FAM9B within its associated signaling pathways.
Furthermore, the activities of FAM9B are modulated by the interaction with various signaling molecules and pathways influenced by chemical compounds like Sphingosine-1-phosphate (S1P), Retinoic acid, and Bisphenol A. S1P, through its receptor-mediated signaling, may foster the phosphorylation of proteins that interact with FAM9B, enhancing its functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a catechin found in green tea, is known for its ability to inhibit DNA methyltransferases. This inhibition may lead to the hypomethylation of the FAM9B gene promoter, which can enhance the expression and functional activity of FAM9B. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels. Increased Ca2+ activates calmodulin-dependent kinases, which may enhance the activity of FAM9B by phosphorylation of associated proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent PKC activator. PKC phosphorylates serine and threonine residues on proteins, potentially leading to the activation of signaling cascades that enhance the activity of FAM9B. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P acts on its specific G protein-coupled receptors, which may lead to downstream phosphorylation events enhancing the activity of FAM9B within related signaling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, through its nuclear receptors, regulates gene expression. It may enhance FAM9B activity by increasing the expression of genes encoding proteins that facilitate FAM9B's function. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A, known to interact with estrogen receptors, can alter gene expression, potentially leading to the upregulation of FAM9B or proteins that modulate its activity. | ||||||
Oxytocin acetate salt | 50-56-6 | sc-279938 sc-279938A sc-279938B sc-279938C sc-279938D sc-279938E | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $60.00 $180.00 $337.00 $663.00 $969.00 $1836.00 | 4 | |
Oxytocin can activate signaling pathways that enhance the activity of proteins like FAM9B, promoting interactions essential for FAM9B's functional enhancement. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for various enzymes and can directly stabilize proteins or activate enzymes that modify FAM9B, enhancing its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects various cellular targets, including transcription factors and enzymes, and may enhance FAM9B activity by affecting signaling pathways that FAM9B is involved in. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can enhance gene expression, potentially increasing expression of genes related to FAM9B activity. | ||||||