FAM92A1 Inhibitors

CBY1 interacting BAR domain containing 1" (CIBAR1) is a protein that is implicated in cellular processes such as endocytosis and membrane remodeling due to its BAR (Bin/Amphiphysin/Rvs) domain. The BAR domain is known for its ability to sense and induce membrane curvature, suggesting that CIBAR1 might have a role in vesicular trafficking pathways, where membrane bending is a critical step.The interaction of CIBAR1 with CBY1, which stands for "Chibby family member 1," hints at a connection to the Wnt signaling pathway, where CBY1 acts as a regulator. CBY1 is known to modulate beta-catenin-mediated transcription, which is central to cell proliferation, differentiation, and genetic stability. Through its association with CBY1, CIBAR1 may influence the Wnt/beta-catenin signaling cascade, potentially affecting the distribution or function of beta-catenin within the cell.

Research suggests that the BAR domain proteins, including CIBAR1, participate in the sculpting of cell membranes and can contribute to the formation of various membrane-associated structures. This function is essential in numerous cellular activities, such as cytokinesis, cell migration, and organelle biogenesis.While the exact molecular mechanisms by which CIBAR1 exerts its influence remain to be fully characterized, it is likely to be involved in the dynamic reorganization of the cytoskeleton in conjunction with membrane deformation processes. It might also have a role in the spatial regulation of signaling pathways through its interactions with other protein partners, like CBY1.