FAM81A Activators
FAM81A activators are chemical compounds that target the FAM81A protein, a relatively obscure member of the human proteome whose functions have not been extensively characterized. FAM81A, which stands for "family with sequence similarity 81, member A," represents a protein that is encoded by the FAM81A gene in humans. However, activators of this protein influence its activity, presumably modulating its function. These activators could be small molecules, peptides, or other forms of ligands that interact with FAM81A to increase its activity, stability, or to affect its interaction with other cellular components.
The design and discovery of FAM81A activators entail a complex process that involves understanding the structural biology of the protein. This can include studying the three-dimensional conformation of FAM81A, identifying active sites or regions of the protein that are amenable to binding, and elucidating the protein's interaction with other cellular components. Once potential binding sites are identified, activators are developed through a process that may involve computational modeling, medicinal chemistry, and various screening techniques. The activators themselves are likely to be highly specific to FAM81A, given the precision required to modulate a protein's activity without off-target effects. The specificity is achieved through a careful process of optimization, where the chemical structure of the activator is fine-tuned to improve its interaction with FAM81A. This optimization process is essential to achieving the desired level of activity modulation, ensuring that the activator effectively influences FAM81A's role in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA acts as a direct activator of protein kinase C (PKC). PKC-mediated phosphorylation can lead to the activation of downstream proteins. If FAM81A is within the PKC signaling axis, PMA can activate PKC, which may then enhance the functional activity of FAM81A. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a known inhibitor of certain protein kinases. By inhibiting competitive kinases, EGCG may increase the relative activity of pathways that FAM81A is involved in, thus indirectly enhancing the activity of FAM81A. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can activate calcium-dependent proteins and signaling cascades. If FAM81A is part of, or regulated by, calcium-dependent pathways, ionomycin could enhance its activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular cAMP levels, potentially leading to the activation of PKA. If FAM81A is regulated by PKA, the increased cAMP from isoproterenol could indirectly enhance FAM81A activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
This is a cell-permeable cAMP analog that directly activates cAMP-dependent pathways. If FAM81A is modulated by PKA or other cAMP-responsive elements, 8-Bromo-cAMP could enhance FAM81A activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, okadaic acid could increase phosphorylation levels of proteins, potentially enhancing the activity of FAM81A if it is regulated by phosphorylation. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc pyrithione can modulate various cellular signaling pathways, including those involving metalloproteins. If FAM81A interacts with or is regulated by metalloproteins, zinc pyrithione could indirectly enhance its activity. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 is a modulator of PKC. If FAM81A is downstream of PKC or is regulated by PKC-mediated signaling, bryostatin 1 can enhance the activity of FAM81A. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). If FAM81A activity is negatively regulated by GSK-3, inhibition by lithium chloride could lead to enhanced activity of FAM81A. | ||||||