FAM81A Inhibitors
FAM81A inhibitors represent a class of chemical compounds specifically designed to interfere with the function of FAM81A, a protein encoded by the FAM81A gene. The activity of FAM81A is vital for certain cellular processes, and thus its inhibition can have notable effects on cellular function. These inhibitors work by various mechanisms to reduce the activity of FAM81A, with each compound targeting the protein or its pathways in a unique manner. Some compounds may bind directly to the active site of FAM81A, preventing its interaction with other cellular components essential for its function. Others might interfere with the protein's structure, causing a conformational change that results in a loss of function. Some FAM81A inhibitors may also act indirectly; for example, by inhibiting upstream signaling molecules or enzymes that are necessary for FAM81A activation. The specificity of these inhibitors is critical as it ensures that the inhibition of FAM81A does not inadvertently affect similar proteins and pathways within the cell.
The inhibition of FAM81A by these chemical compounds plays a significant role in altering the biochemical pathways in which FAM81A is involved. By blocking the functional activity of FAM81A, these inhibitors can disrupt the signaling events and biological processes that FAM81A typically mediates. This interference might lead to the suppression of specific gene expressions or the alteration of metabolic pathways that are directly or indirectly governed by FAM81A activity. The effect of these inhibitors is strictly at the molecular and cellular levels, focusing on the biochemical interactions and transformations that occur due to the presence and activity of FAM81A. The intricate nature of these chemical inhibitors showcases the complex interplay between small molecule inhibitors and protein function, emphasizing the depth of understanding required to manipulate such biological processes precisely.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MAPK/ERK kinase 1/2 (MEK1/2). FAM81A, being part of the cellular machinery, is affected when MEK1/2 is inhibited, leading to altered cell signaling and thus decreased FAM81A activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, the Akt pathway, which is involved in cell survival and proliferation, is dampened, potentially decreasing the functional activity of FAM81A if it is linked to these cellular processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. By inhibiting p38 MAP kinase, it affects the cellular stress response that might be involved in the regulation of FAM81A activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of ROCK kinases. Inhibition of ROCK kinases can lead to changes in cell shape and motility, which could affect the functional role of FAM81A if it is associated with cytoskeletal dynamics. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that blocks the MAPK/ERK pathway. Inhibition of this pathway can lead to reduced activity of downstream proteins, potentially including FAM81A if it is associated with this pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, it can alter transcription factor activity and inflammatory responses, which could indirectly influence FAM81A activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Inhibition of mTOR signaling can affect cell growth and proliferation, which could in turn influence FAM81A activity if it is involved in these processes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. By inhibiting proteasome activity, it can lead to increased levels of cellular proteins targeted for degradation, which might affect FAM81A function indirectly. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, similar to LY294002. It can suppress the Akt pathway and affect cell survival, potentially impacting FAM81A if it is involved in related signaling events. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR inhibitor. By blocking EGFR signaling, it can affect cell proliferation and survival pathways, which could decrease FAM81A activity if it is connected to EGFR signaling. | ||||||