FAM65A Activators

Forskolin, by elevating cAMP levels, activates PKA, which can lead to the phosphorylation and regulation of proteins within the cell. Ionomycin, through its capacity to increase intracellular calcium, triggers signaling cascades involving calcium-dependent kinases and phosphatases, which are known to influence protein activities. Lithium chloride and SB216763 both serve as inhibitors of GSK-3β, a kinase that has widespread effects on protein phosphorylation, and thus, on their activity. MG132, by inhibiting the proteasome, prevents the degradation of proteins, potentially increasing the levels and function of various proteins, including FAM65A. PD0325901 and SP600125 target the MAPK/ERK pathway and the JNK pathway, respectively, with broad implications for protein activity modulation. LY294002 disrupts PI3K signaling, which can have far-reaching effects on protein activities due to the central role of PI3K/AKT in cell survival and metabolism.

PP2 and Y-27632 target Src family kinases and Rho-associated kinases (ROCK), respectively, both of which are integral to the regulation of the actin cytoskeleton and signal transduction, thereby influencing protein functions. KN-93 inhibits CaMKII, which is involved in calcium signaling pathways that affect a plethora of cellular processes. AICAR activates AMPK, a master regulator of cellular energy homeostasis, which can have extensive effects on cellular signaling pathways and protein functions.