FAM59A Inhibitors
Chemical inhibitors of FAM59A target various signaling pathways that are essential for the protein's functional activity within the cell. Staurosporine, a broad-spectrum protein kinase inhibitor, can inhibit FAM59A by blocking kinase activity crucial for signal transduction that FAM59A is involved in. Similarly, LY294002 and wortmannin, both inhibitors of PI3K, can prevent the activation of the PI3K/Akt pathway, thereby functionally inhibiting FAM59A, which may utilize this pathway for intracellular signaling. The inhibition of the MEK/ERK pathway by U0126, PD98059, and SL327 also represents a method by which FAM59A can be functionally inhibited, as the blockade of this signaling route can prevent the activation of downstream components that FAM59A may influence.
Furthermore, SP600125 and Dasatinib focus on the MAPK and Src family kinase pathways, respectively. By inhibiting JNK with SP600125, FAM59A can be functionally inhibited if it is involved in JNK-mediated signaling processes. Dasatinib can inhibit FAM59A through its action on Src family kinases, which are integral to various signaling pathways that FAM59A might be a part of. SB203580's selective inhibition of p38 MAP kinase can lead to functional inhibition of FAM59A by preventing stress response signaling in which FAM59A may participate. Rapamycin, by inhibiting mTOR, can block a pathway instrumental in cell growth and proliferation that may involve FAM59A. PP2 and triciribine, as inhibitors of Src family kinases and Akt respectively, can functionally inhibit FAM59A by disrupting the signaling cascades these kinases regulate, including those that FAM59A may use to mediate its cellular effects.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. FAM59A, as a protein involved in intracellular signaling, may be functionally inhibited by staurosporine's ability to block kinase activity, which is crucial for signal transduction that FAM59A might be a part of. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, a kinase involved in the Akt pathway. Since FAM59A is a signaling protein, its activity can be functionally inhibited by LY294002's suppression of the PI3K/Akt pathway, which is essential for various signaling processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which is part of the MAPK/ERK pathway. By inhibiting MEK, PD98059 can functionally inhibit FAM59A by preventing the activation of downstream signaling components which FAM59A might influence. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK signaling pathways. Inhibition of JNK by SP600125 can lead to functional inhibition of FAM59A, if FAM59A is involved in JNK-mediated signaling processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. FAM59A, by being a part of cellular signaling, may be functionally inhibited by SB203580 through the blockade of the p38 MAPK pathway, which is involved in stress responses and cytokine production. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, known to also affect the Akt pathway. FAM59A's activity can be functionally inhibited by wortmannin by its disruption of the PI3K/Akt pathway, which is pivotal for transmitting cellular signals. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor and could functionally inhibit FAM59A by blocking the mTOR pathway, which is instrumental in cell growth and proliferation, where FAM59A might play a role. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor. Since Src kinases participate in various signaling pathways, FAM59A could be functionally inhibited by PP2 through the inhibition of Src family kinases that may interact with FAM59A as part of signaling cascades. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an inhibitor of Akt, also known as protein kinase B. FAM59A can be functionally inhibited by triciribine as it targets the Akt pathway, which FAM59A may utilize to mediate intracellular signaling. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib is a Bcr-Abl and Src family kinase inhibitor. It can functionally inhibit FAM59A by targeting Src kinases, which are involved in numerous signaling pathways that FAM59A may be a part of. | ||||||