FAM21A Activators
FAM21A, as a component of the WASH complex, plays a crucial role in actin polymerization and cytoskeletal dynamics. Activation of adenylyl cyclase leading to increased cAMP levels can enhance the actin polymerization process that FAM21A regulates. Similarly, stabilization of actin filaments increases actin polymerization, which falls under the regulatory scope of the WASH complex. Phosphorylation by protein kinase C also influences proteins in actin assembly, potentially augmenting FAM21A's contribution to actin dynamics. Additionally, the inhibition of protein phosphatases leads to a rise in phosphorylation of proteins, a modification that can enhance actin cytoskeleton dynamics, in which FAM21A is implicated. The actin nucleation activity of the WASH complex can be augmented by inhibiting specific GTPases, thereby amplifying FAM21A's role in actin filament organization.
Further modulation of FAM21A activity arises from alterations in actin-myosin interactions, as the inhibition of myosin II ATPase activity can indirectly promote FAM21A's function in actin filament elongation. Inhibitors that bind to actin monomers or filaments result in altered actin dynamics, leading to an increased dependence on FAM21A for actin network formation. Inhibition of GSK-3β induces changes in cytoskeletal organization and may upregulate pathways that increase FAM21A activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC) which can phosphorylate proteins involved in actin filament assembly, potentially augmenting FAM21A-mediated actin dynamics. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Stabilizes actin filaments and can increase actin polymerization, which is regulated by the WASH complex where FAM21A is a component. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation of proteins that could enhance actin cytoskeleton dynamics influenced by FAM21A. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
Inhibitor of Cdc42 GTPase, potentially augmenting the actin nucleation activity of the WASH complex, thereby increasing FAM21A's role in actin dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor that may lead to changes in actin cytoskeleton organization, indirectly affecting FAM21A's function in actin-related processes. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Inhibits myosin II ATPase activity, potentially affecting actin-myosin interactions and indirectly promoting functions of FAM21A in actin filament elongation. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Binds to actin monomers preventing polymerization, indirectly influencing the dynamic regulation of the actin cytoskeleton by FAM21A. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Binds to the barbed ends of actin filaments, leading to altered actin dynamics that could increase the involvement of FAM21A in actin network formation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β leading to changes in cytoskeletal organization and potential upregulation of pathways where FAM21A is involved. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
GSK-3β inhibitor that can alter cytoskeletal dynamics and possibly enhance the activity of FAM21A in actin remodeling processes. | ||||||