FAM21A Inhibitors
FAM21A inhibitors consist of chemical compounds that impair the functional activity of FAM21A by disrupting the actin cytoskeleton and endocytosis pathways which the protein plays a role in regulating. These inhibitors work through different mechanisms, such as by blocking the polymerization of actin filaments, inhibiting nucleation-promoting factors, or interfering with GTPase activity, all of which are vital to the actin dynamics that FAM21A modulates. For instance, some compounds prevent the addition of new monomers to the growing actin filaments or bind to actin monomers themselves, thereby stalling the dynamic rearrangement of the cytoskeleton. This disruption in actin dynamics can hinder FAM21A's involvement in the WASH complex, which is integral to cytoskeletal maintenance and vesicular trafficking. Further, inhibitors that impede the ATPase activity of motor proteins like non-muscle myosin II directly affect the contractile machinery of the cell, which is essential for processes that FAM21A is known to influence.
In addition to targeting the actin cytoskeleton, FAM21A inhibitors also affect endocytosis, a pathway where FAM21A is implicated due to its association with the WASH complex. Certain inhibitors directly disrupt the endocytic machinery by interfering with GTPase function or by inhibiting key proteins involved in vesicle scission from the plasma membrane. This perturbation in endocytosis can indirectly lead to a reduction in FAM21A functionality, as the protein's role is closely linked to the efficient trafficking of cellular components.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that targets a wide range of kinases. Inhibition of these kinases can impede endocytosis, affecting FAM21A's role in actin filament capping and potentially inhibiting its function in the WASH complex. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
An inhibitor of the N-WASP, which is a crucial regulator of actin polymerization. By inhibiting N-WASP, wiskostatin indirectly disrupts the actin cytoskeleton dynamics that FAM21A is involved in through the WASH complex. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
A compound that binds to actin monomers and prevents their polymerization. This directly impairs the actin cytoskeleton remodeling where FAM21A is implicated as a regulatory component of the WASH complex. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
An inhibitor of the Arp2/3 complex that prevents actin nucleation, a process essential for actin filament assembly that FAM21A regulates through the WASH complex. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
A selective inhibitor of Cdc42, a small GTPase involved in actin polymerization. By inhibiting Cdc42, ML141 can indirectly hinder the processes that FAM21A facilitates within the WASH complex. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
A small molecule that inhibits dynamin, a GTPase involved in clathrin-mediated endocytosis. By disrupting endocytosis, dynasore indirectly affects the trafficking role of FAM21A in the WASH complex. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
An inhibitor of non-muscle myosin II ATPase activity. By inhibiting myosin II, blebbistatin disrupts actin-myosin interactions which can influence the processes that FAM21A regulates via the WASH complex. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A selective inhibitor of ROCK kinases which control actin cytoskeleton organization. Inhibition of ROCK can alter actin dynamics, thereby indirectly affecting FAM21A's role in actin-related processes via the WASH complex. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
A cyclodepsipeptide that stabilizes actin filaments and prevents their disassembly. This can impair actin dynamics and indirectly inhibit FAM21A function associated with the WASH complex-mediated actin filament turnover. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
A potent inhibitor of actin filament elongation and depolymerization, disrupting the dynamic state of the actin cytoskeleton and consequently the function of FAM21A in the WASH complex. | ||||||