FAM137B Inhibitors
Golgi-associated RAB2 interactor 1A (GARI1A) is a protein involved in regulating intracellular transport and vesicle trafficking within the cell. It is encoded by the GARI1A gene and primarily localized to the Golgi apparatus, a cellular organelle crucial for protein modification, sorting, and trafficking.As its name suggests, GARI1A interacts with RAB2, a small GTPase protein known to regulate vesicular transport between the endoplasmic reticulum (ER) and the Golgi apparatus. The interaction between GARI1A and RAB2 suggests a role for GARI1A in modulating RAB2-mediated vesicle trafficking processes.Research suggests that GARI1A may participate in the maintenance of Golgi structure and function. It is proposed to be involved in the tethering or docking of transport vesicles to the Golgi membrane, facilitating their fusion and cargo delivery. This function is essential for the proper sorting and trafficking of proteins within the secretory pathway.
Furthermore, GARI1A may play a role in regulating the specificity and efficiency of vesicle transport between the ER and the Golgi apparatus. By interacting with RAB2 and potentially other proteins involved in vesicle trafficking, GARI1A could contribute to the coordination of vesicular transport processes, ensuring the accurate delivery of cargo molecules to their destinations within the cell.Dysregulation of GARI1A expression or function may disrupt normal Golgi function and protein trafficking pathways, leading to cellular dysfunction and disease. Abnormalities in Golgi structure and function have been implicated in various pathological conditions, including neurodegenerative diseases, cancer, and congenital disorders of glycosylation.Overall, Golgi-associated RAB2 interactor 1A plays a critical role in regulating intracellular vesicle trafficking and maintaining the integrity and function of the Golgi apparatus. Further research into its molecular mechanisms and cellular functions will deepen our understanding of its role in cellular homeostasis and disease pathogenesis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits topoisomerase II, which is involved in DNA replication and transcription. Inhibition of topoisomerase II activity can lead to DNA damage and apoptosis, potentially inhibiting GARI1A expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase activity, leading to the suppression of transcription. This inhibition of gene expression could potentially include the expression of GARI1A. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis by interfering with ribosome function. By preventing new protein synthesis, it may lead to decreased expression of GARI1A and other proteins. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Puromycin is an antibiotic that causes premature chain termination during protein synthesis. Inhibition of protein synthesis can result in decreased expression of GARI1A and other proteins. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin inhibits topoisomerase II, resulting in DNA damage and inhibition of transcription. This could lead to decreased expression of GARI1A and other genes. | ||||||
Streptozotocin (U-9889) | 18883-66-4 | sc-200719 sc-200719A | 1 g 5 g | $110.00 $510.00 | 152 | |
Streptozocin is an alkylating agent that damages DNA. DNA damage can lead to the activation of DNA repair mechanisms, potentially resulting in alterations in gene expression, including GARI1A. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Mitomycin C is an alkylating agent that crosslinks DNA, inhibiting DNA replication and transcription. This inhibition of gene expression could affect the expression of GARI1A and other genes. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil is a pyrimidine analog that interferes with DNA and RNA synthesis. Inhibition of nucleic acid synthesis may lead to decreased expression of GARI1A and other genes. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin induces DNA strand breaks, leading to DNA damage and activation of DNA repair mechanisms. This could result in alterations in gene expression, potentially affecting GARI1A expression. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone inhibits topoisomerase II, causing DNA damage and interference with DNA replication and transcription. This inhibition could potentially lead to decreased expression of GARI1A. | ||||||