FAM135A Inhibitors
Chemical inhibitors of FAM135A can exert their inhibitory effects through several mechanisms involving the modulation of signaling pathways that regulate the activity, phosphorylation state, and function of this protein. Staurosporine, a broad kinase inhibitor, can inhibit kinases that phosphorylate FAM135A, thus preventing its activation. Bisindolylmaleimide I targets Protein Kinase C (PKC), which, if involved in phosphorylating FAM135A, can result in reduced FAM135A activity upon inhibition. LY294002 and Wortmannin, both PI3K inhibitors, can diminish the activation of downstream targets in the PI3K/Akt pathway, decreasing the phosphorylation and subsequent activity of FAM135A. U0126 and PD98059, which inhibit MEK1/2 and MEK respectively, can lead to reduced ERK activity and potentially less phosphorylation of FAM135A if it is regulated by the MAPK/ERK pathway.
Continuing with the theme of pathway-specific inhibition, SB203580 and SP600125 target the p38 MAP kinase and JNK respectively, which, when inhibited, can lead to a decrease in FAM135A function if it is regulated by these kinases. Rapamycin, an mTOR inhibitor, can suppress the mTOR pathway, which might reduce FAM135A activity if mTOR is a regulator of FAM135A. LFM-A13 targets Bruton's tyrosine kinase (Btk), inhibiting its activity can lead to a downstream decrease in FAM135A function if Btk is part of the FAM135A regulatory network. Gö 6983 inhibits several PKC isoforms, potentially decreasing FAM135A activity if PKC isoforms phosphorylate and activate FAM135A. Lastly, PP2, which inhibits Src family kinases, can reduce FAM135A activity if Src family kinases are involved in the activation or regulation of FAM135A. Each of these chemical inhibitors targets specific kinases or pathways that, when inhibited, are capable of reducing the functional activity of FAM135A through a cascade of deactivation within the cell's signaling networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine inhibits a broad range of protein kinases. Given that FAM135A is likely to be regulated by phosphorylation like many cellular proteins, inhibition of kinases responsible for FAM135A phosphorylation would inhibit FAM135A function. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I specifically inhibits Protein Kinase C, which is involved in numerous signaling pathways. PKC inhibition can lead to decreased phosphorylation and subsequent inhibition of FAM135A if PKC is upstream in its signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. Since PI3K is part of the PI3K/Akt pathway, which regulates many proteins through phosphorylation, inhibiting this pathway can inhibit the phosphorylation and function of FAM135A. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor that prevents the activation of downstream targets in the PI3K/Akt pathway, potentially inhibiting the phosphorylation and activity of FAM135A. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream in the MAPK/ERK pathway. Inhibition of this pathway can lead to decreased ERK activity and potentially inhibit the function of FAM135A if ERK is a regulatory kinase for FAM135A. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 selectively inhibits MEK, which could inhibit ERK activation, potentially leading to inhibition of FAM135A function if FAM135A is regulated by the MAPK/ERK pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase and would inhibit the function of FAM135A if p38 MAP kinase is involved in its phosphorylation or regulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which may lead to inhibition of FAM135A function if JNK is involved in its activation through phosphorylation or other regulatory mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a central protein in the PI3K/AKT/mTOR pathway. Inhibition of mTOR can lead to inhibition of FAM135A if mTOR influences the function or regulation of FAM135A. | ||||||
LFM-A13 | 62004-35-7 | sc-203623 sc-203623A | 10 mg 50 mg | $119.00 $670.00 | ||
LFM-A13 is an inhibitor of Bruton's tyrosine kinase (Btk). Btk inhibition can result in inhibition of FAM135A function if Btk is involved in the signaling pathways that regulate FAM135A. | ||||||