FAM123A Activators
APC membrane recruitment protein 2 (APC2) is a protein that plays a critical role in the regulation of cell division and signaling pathways related to cell adhesion and migration. APC2 is encoded by the gene ANKRD28 and is a part of the Wnt signaling pathway, which is pivotal in the regulation of gene expression, cellular growth, and embryonic development.As a component of the adenomatous polyposis coli (APC) protein complex, APC2 is involved in the destruction complex that regulates the levels of β-catenin, a key effector in the Wnt pathway. By influencing β-catenin stability, APC2 indirectly affects gene transcription and thereby has a hand in controlling cell proliferation and differentiation.
APC2 is also known to interact with microtubules and contribute to the stabilization of the cytoskeleton. This interaction is vital for proper mitotic spindle assembly during cell division. Moreover, the protein has been implicated in the migration and adhesion of cells by organizing cell matrix adhesions and influencing the actin cytoskeleton.The dysfunction or mutation of APC2 can lead to aberrant activation of the Wnt signaling pathway, which is often associated with the development of colorectal cancers and other types of tumors. Thus, APC2 has a tumor suppressor function, and its loss of function can disrupt the regulation of cell growth, leading to the formation of polyps and subsequent malignant transformation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK-3β, a key component of the Wnt pathway, potentially impacting AMER2 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Involved in cell differentiation, Retinoic Acid might indirectly impact AMER2 through Wnt pathway modulation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 has roles in cell growth and differentiation, potentially affecting AMER2 via Wnt signaling. | ||||||
Biochanin A | 491-80-5 | sc-205603 sc-205603A | 100 mg 250 mg | $77.00 $132.00 | ||
A natural isoflavone that may modulate Wnt signaling, potentially influencing AMER2 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects multiple signaling pathways and could indirectly modulate AMER2, particularly in Wnt signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can modulate various signaling pathways, potentially impacting Wnt signaling and AMER2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, EGCG can influence several signaling pathways, possibly including Wnt/AMER2. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, might affect Wnt signaling, potentially impacting AMER2. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Important for cell growth and reproduction, Folic Acid might indirectly influence AMER2 through Wnt signaling. | ||||||