FAM115C Activators
FAM115C Activators encompass a spectrum of chemical compounds that initiate a variety of biochemical pathways, ultimately leading to the enhanced functional activity of FAM115C. For instance, compounds such as Forskolin and 8-Bromo-cAMP exert their effects by increasing intracellular cAMP levels, which leads to the activation of Protein Kinase A (PKA). Given that FAM115C could be a substrate for PKA, these activators may promote its phosphorylation and activation. The diacylglycerol analog PMA, known for activating protein kinase C (PKC), and Sphingosine-1-phosphate, which modulates signaling through G protein-coupled receptors, both have the potential to initiate signaling cascades that culminate in the phosphorylation and subsequent activation of FAM115C, assuming there is a regulatory relationship between PKC or GPCR pathwaysand FAM115C. Furthermore, the ionophores Ionomycin and A23187 (Calcimycin) increase intracellular calcium levels, potentially triggering calcium-dependent kinases that may phosphorylate and activate FAM115C.
The modulation of intracellular phosphorylation states is a common theme among FAM115C activators, as evidenced by the use of chemicals like Thapsigargin and Okadaic Acid. Thapsigargin disrupts calcium homeostasis by inhibiting the sarco/endoplasmic reticulum Ca2+ ATPase, leading to a rise in cytosolic calcium that can activate downstream kinases. In contrast, Okadaic Acid impedes the action of protein phosphatases, maintaining proteins in a phosphorylated state that could favor FAM115C activation. Additionally, fatty acids such as Oleic Acid may alter membrane dynamics and protein interactions, possibly creating an environment conducive to FAM115C activation. Epigallocatechin gallate (EGCG) and Anisomycin introduce further layers of regulation through kinase inhibition and activation of stress-activated protein kinases, potentially enhancing FAM115C activity via these routes. Lastly, Zinc Pyrithione's capability to activate MAPK signaling provides another avenue through which FAM115C could be phosphorylated and activated, emphasizing the diverse yet interconnected pathways through which these activators exert their influence on FAM115C function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diester of phorbol and functions as a protein kinase C (PKC) activator. PKC activation can lead to downstream signaling cascades that potentially enhance the activity of FAM115C if it is regulated by PKC-mediated phosphorylation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cAMP analog that resists degradation by phosphodiesterases, thereby prolonging the activation of cAMP-dependent pathways. This can lead to sustained PKA activity and may enhance the phosphorylation and activity of FAM115C if it is a PKA substrate. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium levels may activate calmodulin-dependent kinases, which could lead to the activation of FAM115C if it is sensitive to calcium-dependent signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium. This calcium flux may activate calcium-dependent kinases and phosphatases that could enhance FAM115C activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that acts through G protein-coupled receptors to modulate cellular signaling pathways. Activation of these pathways may lead to phosphorylation events that enhance the activity of FAM115C. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid is a monounsaturated fatty acid that can be integrated into cellular membranes, influencing membrane fluidity and signaling. It may impact membrane-associated proteins and kinases, potentially enhancing the activity of FAM115C through changes in membrane dynamics or associated signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium, similarly to ionomycin, which can activate calcium-dependent protein kinases and phosphatases to enhance the activity of FAM115C. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels within the cell. This can indirectly enhance FAM115C activity if it is regulated by phosphorylation and dephosphorylation mechanisms. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibition properties. It may alter signaling pathways by inhibiting certain kinases, potentially leading to an enhanced activity of FAM115C through altered phosphorylation states. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases (SAPKs/JNKs). Activation of these kinases may enhance the activity of FAM115C through stress response signaling pathways. | ||||||