Date published: 2025-9-11

1-800-457-3801

SCBT Portrait Logo
Seach Input

FAK Activators

FAK Activators are a class of chemical compounds specifically designed to increase the activity of Focal Adhesion Kinase (FAK), a non-receptor protein tyrosine kinase. FAK plays a central role in various cellular processes such as adhesion, migration, and survival. Activators of FAK typically modulate the enzyme by enhancing its phosphorylation, which is a key step in its activation cycle. By increasing the level of FAK activation, these compounds influence cellular events connected to FAK signaling pathways. Many of these activators interact directly with the kinase domain of FAK or the associated regulatory domains. Their mode of action often involves stabilization of the active conformation of FAK, thereby facilitating its autophosphorylation and subsequent activation of downstream signaling cascades. Understanding the molecular mechanisms by which FAK activators work is essential for a comprehensive view of cell biology. The role of FAK in cellular adhesion and migration makes it an interesting target for studying basic cell functions and responses to external stimuli. FAK Activators are thus invaluable tools for researchers interested in dissecting the intracellular events mediated by FAK. Because of their specific focus on FAK activation, these compounds can help elucidate the broader roles of FAK in various signaling pathways. They are often used in conjunction with other molecules that inhibit FAK to better understand the balance of activation and deactivation in cellular processes.

SEE ALSO...

Items 1 to 10 of 11 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Angiotensin II, Human

4474-91-3sc-363643
sc-363643A
sc-363643B
sc-363643C
1 mg
5 mg
25 mg
100 mg
$50.00
$75.00
$260.00
$505.00
3
(1)

Angiotensin II, Human, functions as a potent peptide hormone that engages with specific G protein-coupled receptors, triggering a cascade of intracellular signaling pathways. Its unique amino acid sequence allows for high-affinity binding, leading to the activation of phospholipase C and subsequent inositol trisphosphate production. This interaction modulates calcium ion release, influencing vascular smooth muscle contraction and blood pressure regulation. The compound's stability and reactivity in physiological conditions further enhance its role in the renin-angiotensin system.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic Acid is involved in regulating gene expression. It may stimulate FAK expression by activating various transcription factors involved in cellular differentiation and growth.

β-Estradiol

50-28-2sc-204431
sc-204431A
500 mg
5 g
$62.00
$178.00
8
(1)

Estradiol can increase FAK expression through estrogen receptor pathways, which are known to modulate various signaling mechanisms implicated in cell adhesion and migration.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin activates adenylate cyclase, increasing cAMP levels, which might lead to the induction of FAK expression via cAMP-responsive elements in the FAK gene promoter.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin has been shown to affect multiple signaling pathways, including those that involve FAK. Its potential to induce FAK expression could be attributed to its influence on cellular adhesion and migration mechanisms.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol may influence FAK expression through activation of SIRT1, which has been shown to interact with several signaling pathways involving cell adhesion and migration.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Genistein is a phytoestrogen that has been observed to influence various cellular processes. It could induce FAK expression by interacting with estrogen receptor pathways or other signaling mechanisms.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Quercetin can modulate various cellular processes including those that involve FAK. Its potential to induce FAK may be related to its capacity to modulate oxidative stress and inflammation.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
5 g
100 g
250 g
1 kg
5 kg
$32.00
$66.00
$95.00
$188.00
$760.00
13
(1)

Caffeine might influence FAK expression through its capacity to modulate cAMP and PKA signaling pathways, which are known to be upstream regulators of FAK.

C2 Ceramide

3102-57-6sc-201375
sc-201375A
5 mg
25 mg
$77.00
$316.00
12
(1)

C2 Ceramide has been shown to be involved in cellular stress responses. It may induce FAK expression as a cellular survival mechanism, particularly during apoptotic signaling.