Factor V Inhibitors
Factor V inhibitors are a class of chemical compounds that specifically target and interfere with Factor V, a crucial protein in the coagulation cascade, which plays a pivotal role in blood clot formation. These inhibitors are designed to block the normal functioning of Factor V, it from participating in the clotting process. Factor V, also known as labile factor or proaccelerin, is a coagulation protein that circulates in an inactive form in the bloodstream. When vascular injury occurs, Factor V is activated and contributes to the formation of a stable blood clot. However, in certain medical conditions or situations, uncontrolled blood clotting can be harmful, leading to conditions like deep vein thrombosis (DVT), pulmonary embolism, or stroke. Factor V inhibitors serve as a means to modulate this coagulation factor's activity, thereby regulating the clotting process.The mechanism of action of Factor V inhibitors typically involves binding to Factor V and interfering with its activation or downstream interactions with other coagulation factors. By doing so, these inhibitors disrupt the intricate cascade of events that lead to clot formation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Warfarin | 81-81-2 | sc-205888 sc-205888A | 1 g 10 g | $73.00 $246.00 | 7 | |
Warfarin inhibits vitamin K epoxide reductase, an enzyme that recycles vitamin K, which is necessary for the post-translational carboxylation of several blood coagulation factors including factor V. Inhibition of this enzyme reduces the coagulation potential and thereby the activity of factor V. | ||||||
Rivaroxaban | 366789-02-8 | sc-208311 | 2 mg | $158.00 | 18 | |
Rivaroxaban directly inhibits Factor Xa, which is upstream of Factor V in the coagulation cascade. This inhibition reduces the generation of thrombin, which is necessary for the activation of factor V. | ||||||
Apixaban | 503612-47-3 | sc-364406 sc-364406A | 10 mg 50 mg | $240.00 $634.00 | 2 | |
Apixaban is an inhibitor of Factor Xa, similar to rivaroxaban, and it indirectly reduces the activation of factor V by decreasing the production of thrombin. | ||||||
Edoxaban | 480449-70-5 | sc-483508 | 25 mg | $522.00 | ||
Edoxaban is also a direct Factor Xa inhibitor. By inhibiting Factor Xa, it suppresses the conversion of prothrombin to thrombin, thereby indirectly reducing factor V activation. | ||||||
Dabigatran | 211914-51-1 | sc-481166 | 5 mg | $205.00 | 1 | |
Dabigatran is a direct thrombin inhibitor that prevents the formation of fibrin clots by inhibiting thrombin. Since thrombin is responsible for the cleavage that activates factor V, dabigatran indirectly inhibits factor V activation. | ||||||
Argatroban | 74863-84-6 | sc-201310 sc-201310A | 10 mg 50 mg | $117.00 $469.00 | 13 | |
Argatroban is a direct thrombin inhibitor, which by inhibiting thrombin, indirectly prevents the activation of factor V. | ||||||
Fondaparinux | 104993-28-4 | sc-507424 | 10 mg | $297.00 | ||
Fondaparinux is a synthetic pentasaccharide that enhances the inhibition of Factor Xa by antithrombin III. This results in reduced thrombin generation and subsequent factor V activation. | ||||||
Bivalirudin | 128270-60-0 | sc-278793 | 5 mg | $110.00 | ||
Bivalirudin directly inhibits thrombin. By doing so, it indirectly inhibits the activation of factor V since thrombin is a necessary activator of factor V. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin potentiates the action of antithrombin III, which inactivates several enzymes in the coagulation cascade, including thrombin and Factor Xa, leading to decreased activation of factor V. | ||||||
Desirudin | 120993-53-5 | sc-507332 | 50 mg | $2950.00 | ||
Desirudin is a direct inhibitor of thrombin. By inhibiting thrombin, it indirectly prevents the cleavage and activation of factor V. | ||||||