You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
Rivaroxaban is an oral, direct inhibitor of Factor X, being developed for the prevention and treatment of arterial and venous thrombosis with a Ki of 0.4 nM. Rivaroxaban also inhibits prothrombinase activity (IC50 = 2.1 nM). Rivaroxaban also shows a similar affinity to purified human (IC50 = 0.7 nM) and rabbit Factor X (IC50 = 0.8 nM), but a lesser potency against purified rat Factor X (IC50 = 3.4 nM). Endogenous human and rabbit Factor X in plasma is inhibited to a similar extent by Rivaroxaban (IC50 = 21 nM and 21 nM, respectively), while 14-fold higher concentrations are required in rat plasma (IC50 = 290 nM). Rivaroxaban exhibits high permeability and polarized transport across Caco-2 cells as a substrate of the P-gp, but exhibits no inhibitory effect on P-gp-mediated drug transport up to concentrations of 100 μM in vitro.
1. Ansell, J., et al. 2004. Drugs. 64: 1-5. PMID: 15586622
2. Kubitza, D., et al. 2005. Clin. Pharmacol. Ther. 78: 412-421. PMID: 16198660
3. Eriksson, B.I., et al. 2005. J. Thromb. Haemost. 3: 103-111. PMID: 15634273
See how others have used Rivaroxaban. Click on the entry to view the PubMed entry .
PMID: # 28170419 Derogis, PB.|Sanches, LR.|de Aranda, VF.|Colombini, MP.|Mangueira, CL.|Katz, M.|Faulhaber, AC.|Mendes, CE.|Ferreira, CE.|França, CN.|Guerra, JC.| et al. 2017. PLoS ONE. 12: e0171272.
PMID: # 26762345 Ku, SK. et al. 2016. Arch. Pharm. Res. 39: 398-408.
PMID: # 25887749 Yoon, EK. et al. 2015. BMB Rep. 48: 577-82.
PMID: # 26126169 Lee, W. et al. 2015. Blood Coagul. Fibrinolysis. 26: 628-34.
PMID: # 25325928 Ku, SK. et al. 2015. Arch. Pharm. Res. 38: 1080-9.
PMID: # 24849036 Lee, W. et al. 2015. Arch. Pharm. Res. 38: 893-903.
PMID: # 24534482 Ku, SK. et al. 2014. Vascul. Pharmacol. 60: 120-6.
PMID: # 24234914 Yoo, H. et al. 2014. Arch. Pharm. Res. 37: 1069-78.
PMID: # 24817443 Ku, SK. et al. 2014. Arch. Pharm. Res. 37: 1454-63.
PMID: # 25020199 Ku, SK. et al. 2014. Fitoterapia. 98: 27-35.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.