Molecular structure of Warfarin, CAS Number: 81-81-2
Warfarin (CAS 81-81-2)
See product citations (7)
Alternate Names:
Coumafene; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin
Application:
Warfarin is A synthetic derivative of coumarin used for preventing thrombosis and embolism
CAS Number:
81-81-2
Purity:
≥98%
Molecular Weight:
308.33
Molecular Formula:
C19H16O4
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Warfarin, which is known as an anticoagulant, stands out as a widely utilized compound in various applications. In the area of scientific research, warfarin is instrumental in exploring pharmacodynamics, pharmacokinetics, blood coagulation mechanics, platelet aggregation, and thrombosis. It is also valuable in analyzing the impact of interactions between different compounds and their effects on organ and tissue systems. The mechanism by which warfarin acts involves the suppression of gamma-glutamyl carboxylase, an enzyme involved in the carboxylation of glutamate residues on clotting factors, thereby hindering the generation of active clotting agents and producing an anticoagulant effect.
Warfarin (CAS 81-81-2) References
- Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. | Rost, S., et al. 2004. Nature. 427: 537-41. PMID: 14765194
- Elevated warfarin metabolism in warfarin-resistant roof rats (Rattus rattus) in Tokyo. | Ishizuka, M., et al. 2007. Drug Metab Dispos. 35: 62-6. PMID: 17012541
- Experimental model of warfarin-associated intracerebral hemorrhage. | Foerch, C., et al. 2008. Stroke. 39: 3397-404. PMID: 18772448
- Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. | Dutton, RJ., et al. 2010. Proc Natl Acad Sci U S A. 107: 297-301. PMID: 20018758
- Transglutaminase 2-mediated activation of β-catenin signaling has a critical role in warfarin-induced vascular calcification. | Beazley, KE., et al. 2012. Arterioscler Thromb Vasc Biol. 32: 123-30. PMID: 22034513
- Quercetin attenuates warfarin-induced vascular calcification in vitro independently from matrix Gla protein. | Beazley, KE., et al. 2013. J Biol Chem. 288: 2632-40. PMID: 23223575
- Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. | Jiang, X., et al. 2016. Eur J Pharmacol. 786: 10-18. PMID: 27212383
- Warfarin accelerated vascular calcification and worsened cardiac dysfunction in remnant kidney mice. | Tsai, MT., et al. 2018. J Chin Med Assoc. 81: 324-330. PMID: 29395943
- Influence of the intestinal microflora on the elimination of warfarin in the rat. | Remmel, RP., et al. 1981. Drug Metab Dispos. 9: 410-4. PMID: 6117438
- Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves. | Price, PA., et al. 1998. Arterioscler Thromb Vasc Biol. 18: 1400-7. PMID: 9743228
- Effects of vitamin K-1 and menaquinone-7 on vascular function and blood pressure in warfarin-induced calcification-model in rats | Siltari, A., Wickholm, N., Kivimäki, A. S., Olli, K., Salli, K., Tiihonen, K.,.. & Vapaatalo, H. 2014. Pharmacology & Pharmacy. 5(12): 1095.
- Calorimetric, spectroscopic and molecular modelling insight into the interaction of gallic acid with bovine serum albumin | Khatun, S., Yasmeen, S., Kumar, A., & Subbarao, N. 2018. The Journal of Chemical Thermodynamics. 122: 85-94.
Inhibitor of:
β thromboglobulin, ACOX1, Afamin, apoH, Arylsulfatase, Arylsulfatase B, Arylsulfatase G, Arylsulfatase J, BPNT1, BSA, C4b, CD42b, cytochrome b5, DIC, DMWD, Elmo3, Enzyme, ES, Factor IX, Factor V, Factor VII, Factor VIII, Factor X, Factor XII, Factor XIII A, GGCX, Gm13718, HPRG, HRASLS, HRG-α, HRG-β1, Humanin, MGP, MK, NCAG1, Norpeg, Olr1590, Olr211, Olr222, Olr257, OMG, OPG, OPLAH, ORG, osteocalcin, OTTMUSG00000019145, PF-4, plasma kallikrein, PN-1, Protein C, Protein Z, PT, RDH13, SerpinA9, SIMP, Sm E, ST8Sia V, SUDD, Tenascin-X, TFPI-2, VKOR, VKORC1, VKORC1L1, and VWF.Activator of:
C1INH, CYP2C9, D-Dimer, Gas6, HCII, Hirudin, HS3ST6, LOC622307, PLGLB1, PLGLB2, Prothrombin, PT, SerpinA1f, SUMF2, TAFI, TLCK, and VKOR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Warfarin, 1 g | sc-205888 | 1 g | $72.00 | |||
Warfarin, 10 g | sc-205888A | 10 g | $162.00 |