Molecular structure of Argatroban, CAS Number: 74863-84-6
Argatroban (CAS 74863-84-6)
See product citations (13)
Alternate Names:
Argipidine
Application:
Argatroban is a peptidomimetic small molecule anticoagulant and direct thrombin inhibitor
CAS Number:
74863-84-6
Purity:
≥98%
Molecular Weight:
508.6
Molecular Formula:
C23H36N6O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Argatroban is prominently used in research focused on its role as a direct thrombin inhibitor. This compound is especially valuable in studies aimed at understanding the regulation of coagulation pathways and thrombin′s role in clot formation. Research involving Argatroban often investigates its impact on thrombin enzymatic activity, providing insights into the mechanism of action and potential modulation of the coagulation cascade. Additionally, Argatroban is utilized in studies examining its effects on fibrin formation and platelet aggregation, key areas in cardiovascular research. Furthermore, its use in biochemical assays helps elucidate the interactions and regulatory processes involved in hemostasis and thrombosis.
Argatroban (CAS 74863-84-6) References
- Argatroban inhibits intraocular fibrin formation after vitrectomy in rabbits. | Maeno, T., et al. 2000. Arch Ophthalmol. 118: 1401-5. PMID: 11030823
- Alternative parenteral anticoagulation with argatroban, a direct thrombin inhibitor. | LaMonte, MP., et al. 2005. Expert Rev Cardiovasc Ther. 3: 31-41. PMID: 15723573
- Pharmacology of argatroban. | Jeske, W., et al. 1999. Expert Opin Investig Drugs. 8: 625-54. PMID: 15992120
- Direct thrombin inhibitors. | Di Nisio, M., et al. 2005. N Engl J Med. 353: 1028-40. PMID: 16148288
- Argatroban: a direct thrombin inhibitor with reliable and predictable anticoagulant actions. | Escolar, G., et al. 2006. Drugs Today (Barc). 42: 223-36. PMID: 16703119
- Argatroban: update. | Yeh, RW. and Jang, IK. 2006. Am Heart J. 151: 1131-8. PMID: 16781211
- Argatroban therapy in patients with coronary artery disease and heparin-induced thrombocytopenia. | Jang, IK., et al. 2008. Cardiology. 109: 172-6. PMID: 17726318
- Argatroban more effectively inhibits the thrombin activity in synovial fluid than naturally occurring thrombin inhibitors. | Asanuma, K., et al. 2016. Cell Mol Biol (Noisy-le-grand). 62: 27-32. PMID: 27262798
- Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function. | Yeh, CH., et al. 2016. PLoS One. 11: e0157471. PMID: 27305147
- Argatroban Attenuates Diabetic Cardiomyopathy in Rats by Reducing Fibrosis, Inflammation, Apoptosis, and Protease-Activated Receptor Expression. | Bulani, Y. and Sharma, SS. 2017. Cardiovasc Drugs Ther. 31: 255-267. PMID: 28695302
- Immobilizing argatroban and mPEG-NH2 on a polyethersulfone membrane surface to prepare an effective nonthrombogenic biointerface. | Dai, Y., et al. 2019. J Biomater Sci Polym Ed. 30: 608-628. PMID: 30907698
- Thrombin inhibitor argatroban modulates bone marrow stromal cells behaviors and promotes osteogenesis through canonical Wnt signaling. | Song, J., et al. 2021. Life Sci. 269: 119073. PMID: 33460666
- Effect of argatroban, a selective thrombin inhibitor, on animal models of cerebral thrombosis. | Tamao, Y. and Kikumoto, R. 1997. Semin Thromb Hemost. 23: 523-30. PMID: 9469624
Inhibitor of:
ADF, BPNT1, DIC, Factor IX, Factor V, Factor VII, Factor VIII, Factor XIII A, Fibrinogen β, HABP2, Hirudin, Olr832, PN-1, Protein Z, Prothrombin, PT, TFPI-2, Thrombin, Thrombin R, and Trypsin-1.Activator of:
APMSF, D-Dimer, HCII, Hirudin, Integrin αVIb, Kininogen, Klkb16, Klkb22, Protein C, TLCK, Trypsin-4, and UNQ9391.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Argatroban, 10 mg | sc-201310 | 10 mg | $117.00 | |||
Argatroban, 50 mg | sc-201310A | 50 mg | $469.00 |