FACE-1 Activators
FACE-1 Activators are a class of chemical compounds that function to modulate the activity of the FACE-1 protein, also known as ZMPSTE24. While these compounds do not directly activate FACE-1, they engage in the modulation of various intracellular pathways and processes that can indirectly influence the function of FACE-1. For instance, both Rapamycin, an mTOR inhibitor, and Metformin, an AMPK activator, can activate metabolic pathways and transcriptional programs that potentially alter the metabolic context in which FACE-1 operates, thereby influencing its function.
Similarly, compounds such as Spermidine, Resveratrol, Quercetin, Epigallocatechin gallate (EGCG), and Curcumin can enhance the process of autophagy, a cellular mechanism that maintains homeostasis by removing unnecessary or dysfunctional components. Autophagy plays a crucial role in the function of FACE-1, as it's involved in the degradation and recycling of proteins and other cellular components. By enhancing autophagy, these compounds can indirectly influence the activity of FACE-1. This is because FACE-1, or ZMPSTE24, is a metalloprotease involved in the maturation of lamin A, a protein that forms part of the nuclear envelope. Dysfunctional lamin A is a substrate of autophagy, and by enhancing this process, these compounds can influence the balance between immature and mature lamin A, indirectly modulating the function of FACE-1.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, can modulate the mTOR pathway. FACE-1, a protein involved in prelamin A processing, can be influenced by alterations in this pathway as mTOR is known to modulate protein synthesis and cellular metabolism, thus potentially affecting the metabolic processes required for ZMPSTE24's function. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin is an AMPK activator. AMPK is a key regulator of cellular energy homeostasis. The activation of AMPK by Metformin can enhance autophagy, which indirectly affects FACE-1 by promoting the degradation of misfolded proteins and potentially enhancing proper protein folding and function. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine is a polyamine that promotes autophagy. By enhancing autophagy, Spermidine can indirectly affect FACE-1's function by promoting the degradation of misfolded proteins and potentially enhancing proper protein folding and function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a sirtuin activator that can modulate the SIRT1 pathway. SIRT1 can deacetylate proteins involved in autophagy, thus potentially affecting FACE-1's function by promoting the degradation of misfolded proteins and enhancing proper protein folding and function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, an active metabolite of vitamin A, is known to modulate gene expression via the nuclear retinoic acid receptor (RAR). It can affect several pathways involved in cell differentiation and proliferation, which can indirectly influence ZMPSTE24's function. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist. Activation of the glucocorticoid receptor can modulate a range of cellular processes including autophagy. Therefore, Dexamethasone can affect FACE-1 by enhancing the degradation of misfolded proteins and potentially enhancing proper protein folding and function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of Adenylyl Cyclase, leading to an increase in intracellular cAMP levels. This can modulate PKA pathway, potentially impacting ZMPSTE24's function as PKA can phosphorylate numerous substrates affecting various cellular processes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid known to modulate autophagy. As such, it can indirectly affect FACE-1's function by promoting the degradation of misfolded proteins and potentially enhancing proper protein folding. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a compound found in green tea that can modulate autophagy. By enhancing autophagy, EGCG can indirectly affect FACE-1's function by promoting the degradation of misfolded proteins and enhancing proper protein folding. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural phenol that can modulate autophagy. By enhancing autophagy, curcumin can indirectly affect FACE-1's function by promoting the degradation of misfolded proteins and potentially enhancing proper protein folding and function. | ||||||