EYA Activators
The first group of EYA activators are those that impact phosphatase activity. Tautomycin and Okadaic Acid are potent protein phosphatase inhibitors. EYA is a unique transcriptional coactivator with intrinsic tyrosine phosphatase activity. These phosphatase inhibitors could enhance EYA's activity by preventing its dephosphorylation, thus indirectly enhancing its function. This could lead to increased transcriptional activation of EYA target genes and influence downstream signaling events.
The second category of EYA activators includes compounds that modulate intracellular cAMP levels. Forskolin, Rolipram, 8-Br-cAMP, Epinephrine, and IBMX all have the potential to increase cAMP levels. EYA proteins can be phosphorylated by protein kinase A (PKA), which is activated by cAMP. Therefore, enhancing cAMP levels could potentially enhance EYA activity. H-89, a PKA inhibitor, could similarly influence EYA function by modulating cAMP-dependent pathways. Lastly, compounds like PMA, U73122, Milrinone, and Calmidazolium Chloride could influence EYA function through their effects on PKC-dependent pathways, phosphoinositide signaling, and calcium signaling, respectively.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is another inhibitor of protein phosphatases and thus may indirectly enhance EYA activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, which can increase intracellular cAMP levels, potentially influencing EYA function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a phosphodiesterase (PDE4) inhibitor, enhancing cAMP levels and potentially affecting EYA activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cAMP analog potentially affecting EYA activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine triggers the production of cAMP, potentially influencing EYA function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, potentially enhancing cAMP levels and impacting EYA activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a PKC activator, which might indirectly influence EYA's function via PKC-dependent pathways. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a phosphodiesterase 3 inhibitor, potentially affecting EYA function by increasing cAMP levels. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $156.00 $612.00 | 27 | |
Calmidazolium chloride is a calmodulin antagonist, potentially affecting EYA function through effects on calcium signaling. | ||||||