EXOSC8 Activators
EXOSC8 activators include diverse chemical compounds that indirectly bolster the functional activity of EXOSC8 by modulating various signaling pathways and molecular interactions. Forskolin, with its ability to elevate intracellular cAMP, along with Rolipram and IBMX, which also increase cAMP by inhibiting phosphodiesterases, activate PKA that could phosphorylate and influence factors associated with the RNA exosome complex where EXOSC8 is critical for RNA degradation. Resveratrol, by activating SIRT1, and Nicotinamide, through its inhibition of sirtuins, may alter the acetylation status of proteins that interact with the RNA exosome complex, optimizing EXOSC8's role in RNA turnover.
Epigallocatechin Gallate and Curcumin, through kinase inhibition and AMPK activation respectively, affect pathways that are crucial for mRNA decay, impacting EXOSC8's function. Retinoic Acid's modulation of gene expression and Sodium Butyrate's histone deacetylase inhibition can alter the expression and modification state of RNA exosome cofactors, which may indirectly amplify EXOSC8's activity. Zinc's role in protein folding and function could stabilize the RNA exosome complex structure, thus supporting EXOSC8's RNA degradation activity. Lastly, Caffeine, another phosphodiesterase inhibitor, and Nicotinamide, with its sirtuin inhibition, can modulate post-translational modifications of proteins within the RNA exosome complex, enhancing EXOSC8's function. Together, these activators contribute to the regulatory landscape of EXOSC8, ensuring its efficient role in RNA metabolism without directly upregulating its expression or activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly increases intracellular cAMP levels, which can lead to the activation of PKA. PKA phosphorylates various substrates, potentially affecting the RNA exosome complex in which EXOSC8 is a core component, thereby enhancing its RNA processing activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4 (PDE4), leading to an accumulation of cAMP in the cell. Elevated cAMP may activate PKA, which can phosphorylate components of the RNA exosome complex, potentially increasing the RNA degradation efficacy of EXOSC8. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a nonspecific inhibitor of phosphodiesterases, causing an increase in cAMP levels. The resulting activation of PKA could enhance the function of the RNA exosome complex by phosphorylation of associated factors, indirectly promoting EXOSC8 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates sirtuin 1 (SIRT1), which can deacetylate and affect the activity of various nuclear proteins. SIRT1 may modify factors that interact with the RNA exosome complex, potentially optimizing EXOSC8 function in RNA turnover. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy and can lead to the selective degradation of cellular components, which could include regulatory factors that inhibit the RNA exosome. This autophagic mechanism may indirectly enhance the RNA degradation activity of EXOSC8. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates AMP-activated protein kinase (AMPK), which is involved in cellular energy homeostasis. Activation of AMPK could modulate the processing bodies (P-bodies) where RNA turnover occurs, thereby impacting the activity of the RNA exosome complex including EXOSC8. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate inhibits multiple kinases and has been shown to affect pathways involved in mRNA decay. It could influence the activity of the RNA exosome complex, potentially increasing the RNA processing function of EXOSC8. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression by activating nuclear receptors. It can influence the expression of cofactors required for the optimal function of the RNA exosome complex, possibly leading to an enhanced activity of EXOSC8 in RNA degradation pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor that leads to a more relaxed chromatin structure and can affect RNA processing. This modification could indirectly enhance EXOSC8 function by altering the availability or modification state of RNA exosome cofactors. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a cofactor for many enzymes and is essential for the proper folding and function of many proteins. It may stabilize the RNA exosome complex structure and augment the RNA degradation activity of EXOSC8. | ||||||