Date published: 2026-3-31

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ExoC3L Inhibitors

Chemical inhibitors of ExoC3L employ a variety of mechanisms to impede the protein's function. Benzyl isothiocyanate and Phenethyl isothiocyanate operate by covalently modifying cysteine residues within the ExoC3L active site, leading to a change in the protein's structure and an inhibition of its enzymatic activity. In a similar vein, allicin reacts with thiol groups on ExoC3L, which can result in the formation of disulfide bonds, potentially disrupting the protein's structure and function. Meanwhile, auranofin targets ExoC3L by irreversibly binding to thiol groups within the protein, thereby inhibiting its thiol-dependent enzymatic activity. Curcumin also exerts its inhibitory effect on ExoC3L by binding to the active site, thereby obstructing substrate access and disrupting enzymatic function. Similarly, capsaicin inhibits ExoC3L by altering the protein's tertiary structure or interfering with substrate access to the active site, leading to diminished enzymatic activity. Other inhibitors, such as ebselen and oltipraz, modulate the activity of ExoC3L through indirect pathways. Ebselen mimics glutathione peroxidase activity, which can lead to the reduction of reactive oxygen species levels. This reduction can attenuate the signaling pathways necessary for ExoC3L optimal activity, resulting in its inhibition. Oltipraz, through its interaction with the Keap1-Nrf2 pathway, can alter cellular redox status, which, in turn, can inhibit ExoC3L function. Sulforaphane also activates the Nrf2 pathway, inducing the expression of detoxification and antioxidant enzymes that may interfere with ExoC3L function. Ellagic acid takes a different approach by chelating metal ions essential for ExoC3L's catalytic activity, thereby obstructing its enzymatic function. Finally, epigallocatechin gallate (EGCG) binds to ExoC3L and hinders its enzymatic function through hydrogen bonds and hydrophobic interactions, disrupting the normal activity of the protein.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Benzyl isothiocyanate

622-78-6sc-204641
sc-204641A
5 g
25 g
$47.00
$156.00
1
(0)

Benzyl isothiocyanate inhibits ExoC3L by covalently modifying cysteine residues in the active site of the protein. This modification alters the protein's structure and function, leading to the inhibition of its enzymatic activity.

Ebselen

60940-34-3sc-200740B
sc-200740
sc-200740A
1 mg
25 mg
100 mg
$33.00
$136.00
$458.00
5
(1)

Ebselen acts as an inhibitor of ExoC3L through its ability to mimic glutathione peroxidase activity, which can lead to the reduction of reactive oxygen species (ROS) levels. Lower ROS levels can attenuate the signaling pathways that are necessary for the optimal activity of ExoC3L, resulting in its inhibition.

Allicin

539-86-6sc-202449
sc-202449A
1 mg
5 mg
$489.00
$1557.00
7
(1)

Allicin inhibits ExoC3L by reacting with thiol groups on the protein, which can lead to the formation of disulfide bonds and potentially disrupt the protein's structure and function, thus inhibiting its activity.

Disulfiram

97-77-8sc-205654
sc-205654A
50 g
100 g
$53.00
$89.00
7
(1)

Disulfiram can inhibit ExoC3L by binding to its metal cofactors, thereby inactivating the protein's enzymatic activity.

Oltipraz

64224-21-1sc-205777
sc-205777A
500 mg
1 g
$286.00
$622.00
(1)

Oltipraz has the ability to modify the Keap1-Nrf2 pathway, which can lead to the alteration of cellular redox status. As ExoC3L activity may be redox-sensitive, the alteration in redox homeostasis can result in the functional inhibition of the protein.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

Sulforaphane is known to inhibit ExoC3L by activating the Nrf2 pathway, which can induce the expression of detoxification and antioxidant enzymes that may interfere with the protein's function.

Phenethyl isothiocyanate

2257-09-2sc-205801
sc-205801A
5 g
10 g
$104.00
$183.00
2
(1)

Phenethyl isothiocyanate can inhibit ExoC3L by interacting with critical amino acids in its active site, which may obstruct the protein's enzymatic mechanism.

Auranofin

34031-32-8sc-202476
sc-202476A
sc-202476B
25 mg
100 mg
2 g
$153.00
$214.00
$4000.00
39
(2)

Auranofin inhibits ExoC3L by irreversibly binding to thiol groups within the protein, leading to the inhibition of its thiol-dependent enzymatic activity.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin inhibits ExoC3L by binding to its active site and disrupting its enzymatic activity. Curcumin's structure allows it to interfere with the substrate binding, thus preventing the protein from performing its function.

Ellagic Acid, Dihydrate

476-66-4sc-202598
sc-202598A
sc-202598B
sc-202598C
500 mg
5 g
25 g
100 g
$58.00
$95.00
$245.00
$727.00
8
(1)

Ellagic acid has the potential to inhibit ExoC3L through the chelation of metal ions that are essential for the protein's catalytic activity. By binding to these metal ions, ellagic acid can obstruct the enzymatic function of ExoC3L.