EVI5 Activators
EVI5 Activators are a class of compounds that enhance the functional activity of EVI5, a protein involved in the regulation of cell cycle progression and cytokinesis. These activators can be broadly categorized based on their targets, such as adenylate cyclase activators, PKA activators, PKA inhibitors, protein phosphatase inhibitors, PKC activators, PKC inhibitors, and calcium ionophores. Forskolin, 8-Br-cAMP, Epinephrine and dbcAMP are adenylate cyclase or cAMP activators that increase the levels of cAMP, leading to the activation of PKA. PKA is known to phosphorylate EVI5, thereby enhancing its activity.
H-89 dihydrochloride is a PKA inhibitor that can modulate the phosphorylation status of EVI5, potentially enhancing its activity. Okadaic acid and Calyculin A inhibit protein phosphatases, preventing the dephosphorylation of EVI5 and thus maintaining or enhancing its activity. Further, PMA is a potent activator of PKC, which can phosphorylate and activate EVI5. Go 6983 is a selective inhibitor of PKC that can modify the phosphorylation status of EVI5, potentially enhancing its activity. Finally, Ionomycin and Thapsigargin are calcium ionophores. They increase intracellular calcium levels, potentiallyactivating calcium-sensitive kinases that may phosphorylate and activate EVI5.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. The elevated cAMP levels activate protein kinase A (PKA), which can phosphorylate and activate EVI5. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog. It activates PKA, which can phosphorylate and activate EVI5. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine can bind to β-adrenergic receptors, activating adenylate cyclase and increasing cAMP levels. This activates PKA, which can phosphorylate and activate EVI5. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). By inhibiting these phosphatases, it prevents the dephosphorylation of EVI5, thus maintaining or enhancing its active state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 (PP1) and 2A (PP2A). This can prevent the dephosphorylation of EVI5, thus maintaining or enhancing its active state. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). PKC can phosphorylate and activate EVI5. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go 6983 is a selective inhibitor of PKC. By inhibiting PKC, it can modify the phosphorylation status of EVI5, potentially enhancing its activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
dbcAMP is a cell-permeable cAMP analog that activates PKA. Activated PKA can phosphorylate and activate EVI5. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore. By increasing intracellular calcium levels, it can activate calcium-sensitive kinases that may phosphorylate and activate EVI5. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin raises intracellular calcium levels by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). This can activate calcium-sensitive kinases that may phosphorylate and activate EVI5. | ||||||